ArticlePloS one2014
Profiles of acute cytokine and antibody responses in patients infected with avian influenza A H7N9.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Dual-Scale StaphAIR: Predictive Modeling for the Diagnosis ofAnalytical chemistry · 2026Article
- Comprehensive Profiling of Inflammatory Factors Revealed That Growth Differentiation Factor-15 Is an Indicator of Disease Severity in COVID-19 Patients.Frontiers in immunology · 2021Article
- Characterization of antibody and memory T-cell response in H7N9 survivors: a cross-sectional analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020Article
- Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus.Journal of immunology research · 2019Article
- Two genetically diverse H7N7 avian influenza viruses isolated from migratory birds in central China.Emerging microbes & infections · 2018Article
- Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017.Emerging infectious diseases · 2018Article
- Serum IFN-γ-induced protein 10 (IP-10) as a biomarker for severity of acute respiratory infection in healthy adults.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2017Article
- C-C Motif Chemokine Ligand 2 (CCL2) Mediates Acute Lung Injury Induced by Lethal Influenza H7N9 Virus.Frontiers in microbiology · 2017Article
- Article
- The role of C5a in acute lung injury induced by highly pathogenic viral infections.Emerging microbes & infections · 2015Review
- Genetic diversity of avian influenza A (H10N8) virus in live poultry markets and its association with human infections in China.Scientific reports · 2015Article
- Proteomic Analysis of Avian Influenza A (H7N9) Patients within a Family Cluster.Journal of global infectious diseasesArticle
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
The influenza A H7N9 virus outbreak in Eastern China in the spring of 2013 represented a novel, emerging avian influenza transmission to humans. While clinical and microbiological features of H7N9 infection have been reported in the literature, the current study investigated acute cytokine and antibody responses in acute H7N9 infection. Between March 27, 2013 and April 23, 2013, six patients with confirmed H7N9 influenza infection were admitted to Drum Tower Hospital, Nanjing, China. Acute phase serum cytokine profiles were determined using a high-throughput multiplex assay. Daily H7 hemagglutinin (HA)-specific IgG, IgM, and IgA responses were monitored by ELISA. Neutralizing antibodies specific for H7N9 viruses were determined against a pseudotyped virus expressing the novel H7 subtype HA antigen. Five cytokines (IL-6, IP-10, IL-10, IFNγ, and TNFα) were significantly elevated in H7N9-infected patients when compared to healthy volunteers. Serum H7 HA-specific IgG, as well as IgM and IgA responses, were detected within 8 days of disease onset and increased in a similar pattern during acute infection. Neutralizing antibodies developed shortly after the appearance of binding antibody responses and showed similar kinetics as a fraction of the total H7 HA-specific IgG responses. H7N9 infection resulted in hallmark serum cytokine increases, which correlated with fever and disease persistence. The novel finding of simultaneous development of IgG, IgM, and IgA responses in acute H7N9 infection points to the potential for live influenza viruses to elicit fast and potent protective antibodies to limit the infection.
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