ArticleBiochemical and biophysical research communications2014
Two-way regulation between cells and aligned collagen fibrils: local 3D matrix formation and accelerated neural differentiation of human decidua parietalis placental stem cells.
Article in Biochemical and biophysical research communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The role of collagen and collagen I/III ratio in pathological conditions: insights into molecular mechanisms and therapeutic approaches.Frontiers in bioengineering and biotechnology · 2025Review
- 3D Bioprinting of Neurovascular Tissue Modeling with Collagen-Based Low-Viscosity Composites.Advanced healthcare materials · 2023Article
- Electrospun Silk Fibroin-CNT Composite Fibers: Characterization and Application in Mediating Fibroblast Stimulation.Polymers · 2022Article
- Distinctive structure, composition and biomechanics of collagen fibrils in vaginal wall connective tissues associated with pelvic organ prolapse.Acta biomaterialia · 2022Article
- Construction and Application of Hepatocyte Model Based on Microfluidic Chip Technique in Evaluating Emodin.Nutrients · 2022Article
- Control of stem cell differentiation by using extrinsic photobiomodulation in conjunction with cell adhesion pattern.Scientific reports · 2022Article
- 3D hydrogel models of the neurovascular unit to investigate blood-brain barrier dysfunction.Neuronal signaling · 2021Review
- A 3-DimensionalCartilage · 2021Article
- Distinctive roles of fibrillar collagen I and collagen III in mediating fibroblast-matrix interaction: A nanoscopic study.Biochemical and biophysical research communications · 2021Article
- Aligned Collagen-CNT Nanofibrils and the Modulation Effect on Ovarian Cancer Cells.Journal of composites science · 2021Article
- Marangoni flows drive the alignment of fibrillar cell-laden hydrogels.Science advances · 2020Article
- Silk-CNT Mediated Fibroblast Stimulation toward Chronic Wound Repair.Recent progress in materials · 2019Article
- New experimental models of the blood-brain barrier for CNS drug discovery.Expert opinion on drug discovery · 2017Review
- E-spun composite fibers of collagen and dragline silk protein: fiber mechanics, biocompatibility, and application in stem cell differentiation.Biomacromolecules · 2015Article
- Biocompatibility of Novel Type I Collagen Purified from Tilapia Fish Scale: An In Vitro Comparative Study.BioMed research international · 2015Article
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Authors and funding
4 authors.
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Abstract
It has been well established that an aligned matrix provides structural and signaling cues to guide cell polarization and cell fate decision. However, the modulation role of cells in matrix remodeling and the feedforward effect on stem cell differentiation have not been studied extensively. In this study, we report on the concerted changes of human decidua parietalis placental stem cells (hdpPSCs) and the highly ordered collagen fibril matrix in response to cell-matrix interaction. With high-resolution imaging, we found the hdpPSCs interacted with the matrix by deforming the cell shape, harvesting the nearby collagen fibrils, and reorganizing the fibrils around the cell body to transform a 2D matrix to a localized 3D matrix. Such a unique 3D matrix prompted high expression of β-1 integrin around the cell body that mediates and facilitates the stem cell differentiation toward neural cells. The study offers insights into the coordinated, dynamic changes at the cell-matrix interface and elucidates cell modulation of its matrix to establish structural and biochemical cues for effective cell growth and differentiation.
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