ArticleJournal of neuropathology and experimental neurology2014
mNos2 deletion and human NOS2 replacement in Alzheimer disease models.
Article in Journal of neuropathology and experimental neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
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- Neutrophils from Alzheimer's disease mice fail to phagocytose debris and show altered release of immune modulators with age.Frontiers in immunology · 2025Article
- Placement of Extracranial Stimulating Electrodes and Measurement of Cerebral Blood Flow and Intracranial Electrical Fields in Anesthetized Mice.Journal of visualized experiments : JoVE · 2023Article
- Alzheimer's Disease Protein Relevance Analysis Using Human and Mouse Model Proteomics Data.Frontiers in systems biology · 2023Article
- Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.Nature biotechnology · 2022Article
- Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity.Journal of neuroinflammation · 2022Article
- Infection and inflammation: New perspectives on Alzheimer's disease.Brain, behavior, & immunity - health · 2022Review
- URMC-099 prophylaxis prevents hippocampal vascular vulnerability and synaptic damage in an orthopedic model of delirium superimposed on dementia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- PGAGP: Predicting pathogenic genes based on adaptive network embedding algorithm.Frontiers in genetics · 2022Article
- CVN-AD Alzheimer's mice show premature reduction in neurovascular coupling in response to spreading depression and anoxia compared to aged controls.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Contrasting Metabolic Insufficiency in Aging and Dementia.Aging and disease · 2021Review
- Likelihood ratio statistics for gene set enrichment in Alzheimer's disease pathways.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Disruption of metabolic, sleep, and sensorimotor functional outcomes in a female transgenic mouse model of Alzheimer's disease.Behavioural brain research · 2021Article
- Loss of tissue-nonspecific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis.Brain, behavior, and immunity · 2020Article
- Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- Multivariate MR biomarkers better predict cognitive dysfunction in mouse models of Alzheimer's disease.Magnetic resonance imaging · 2019Article
- Identifying Vulnerable Brain Networks in Mouse Models of Genetic Risk Factors for Late Onset Alzheimer's Disease.Frontiers in neuroinformatics · 2019Article
- Use of Eflornithine (DFMO) in the Treatment of Early Alzheimer's Disease: A Compassionate Use, Single-Case Study.Frontiers in aging neuroscience · 2018Article
- Modulation of innate immunity of patients with Alzheimer's disease by omega-3 fatty acids.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease-like pathologies. This model demonstrates an altered immune redox state reminiscent of the human disease and capitalizes on data indicating critical differences between human and mouse immune responses, particularly in nitric oxide levels produced by immune activation of the NOS2 gene. Using the APPSwDI(+)/(+)mNos2(-/-) (CVN-AD) mouse strain, we show a sequence of pathologic events leading to neurodegeneration,which include pathologically hyperphosphorylated tau in the perforant pathway at 6 weeks of age progressing to insoluble tau, early appearance of β-amyloid peptides in perivascular deposits around blood vessels in brain regions known to be vulnerable to Alzheimer disease, and progression to damage and overt loss in select vulnerable neuronal populations in these regions. The role of species differences between hNOS2 and mNos2 was supported by generating mice in which the human NOS2 gene replaced mNos2. When crossed with CVN-AD mice, pathologic characteristics of this new strain (APPSwDI(+)/(-)/HuNOS2(tg+)/(+)/mNos2(-/-)) mimicked the pathologic phenotypes found in the CVN-AD strain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.