ArticlePloS one2014
Trehalase regulates neuroepithelial stem cell maintenance and differentiation in the Drosophila optic lobe.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Characterization and Functional Analysis ofInsects · 2021Article
- Three novel trehalase genes from3 Biotech · 2019Article
- Trehalase localization in the cerebral cortex, hippocampus and cerebellum of mouse brains.Journal of advanced research · 2019Article
- Gene Cloning, Prokaryotic Expression, and Biochemical Characterization of a Soluble Trehalase in Helicoverpa armigera Hübner (Lepidoptera: Noctuidae).Journal of insect science (Online) · 2018Article
- Regulation of Carbohydrate Energy Metabolism inGenetics · 2017Review
- Is trehalose an autophagic inducer? Unraveling the roles of non-reducing disaccharides on autophagic flux and alpha-synuclein aggregation.Cell death & disease · 2017Article
- Adaptation to dietary conditions by trehalose metabolism in Drosophila.Scientific reports · 2017Article
- Functional characterization of three trehalase genes regulating the chitin metabolism pathway in rice brown planthopper using RNA interference.Scientific reports · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As one of the major hydrolases in Drosophila, trehalase (Treh) catalyzes the hydrolysis of trehalose into glucose providing energy for flight muscle activity. Treh is highly conserved from bacteria to humans, but little is known about its function during animal development. Here, we analyze the function of Treh in Drosophila optic lobe development. In the optic lobe, neuroepithelial cells (NEs) first divide symmetrically to expand the stem cell pool and then differentiate into neuroblasts, which divide asymmetrically to generate medulla neurons. We find that the knockdown of Treh leads to a loss of the lamina and a smaller medulla. Analyses of Treh RNAi-expressing clones and loss-of-function mutants indicate that the lamina and medulla phenotypes result from neuroepithelial disintegration and premature differentiation into medulla neuroblasts. Although the principal role of Treh is to generate glucose, the Treh loss-of-function phenotype cannot be rescued by exogenous glucose. Thus, our results indicate that in addition to being a hydrolase, Treh plays a role in neuroepithelial stem cell maintenance and differentiation during Drosophila optic lobe development.
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