Evidence map›Paper›PMID 25003138›Full record

SynthesisTheScientificWorldJournal2014

Caffeic acid phenethyl ester as a protective agent against nephrotoxicity and/or oxidative kidney damage: a detailed systematic review.

Sumeyya Akyol, Veli Ugurcu, Aynur Altuntas, Rukiye Hasgul, Ozlem Cakmak, Omer Akyol

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 47 citations in OpenAlex.

  1. Mechanistic pathways andIranian journal of basic medical sciences · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. A Flavonoid-Rich Extract ofMaterials (Basel, Switzerland) · 2022
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Role of Different Blood Purification Nursing Models in Uremic Patients: A Preliminary Report.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
  14. Article
  15. Observational
  16. Article
  17. Review
  18. Review
  19. In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy.Diagnostic and interventional radiology (Ankara, Turkey)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Sumeyya AkyolDivision of Medical Laboratory Techniques, Vocational School of Health Sciences, Turgut Ozal University, Çeşme Durağı Spor Kompleksi Arkası, Ostim, Yenimahalle, 06370 Ankara, Turkey ; Department of Biochemistry, Medical Faculty, Gaziosmanpasa University, Tokat, Turkey.
Veli UgurcuPrivate Bilecik Orhangazi Dialysis Center, Bilecik, Turkey.
Aynur AltuntasAnkara Branch of Council of Forensic Medicine, Ankara, Turkey.
Rukiye HasgulDivision of Medical Laboratory Techniques, Vocational School of Health Sciences, Turgut Ozal University, Çeşme Durağı Spor Kompleksi Arkası, Ostim, Yenimahalle, 06370 Ankara, Turkey.
Ozlem CakmakDepartment of Biology, Faculty of Education, Gazi University, Ankara, Turkey.
Omer AkyolDepartment of Medical Biochemistry, Medical Faculty, Hacettepe University, Ankara, Turkey ; Division of Chemistry, Ankara Branch of Council of Forensic Medicine, Ankara, Turkey.ORCID 0000-0001-5496-9392
Bilecik Şeyh Edebali Üniversitesi · TRCouncil of Higher Education · TRGazi University · TRTokat Gaziosmanpaşa Üniversitesi · TRTurgut Özal University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, antiproliferative, cytotoxic, antiviral, antifungal, and antineoplastic properties. One of the most studied organs for the effects of CAPE is the kidney, particularly in the capacity of this ester to decrease the nephrotoxicity induced by several drugs and the oxidative injury after ischemia/reperfusion (I/R). In this review, we summarized and critically evaluated the current knowledge regarding the protective effect of CAPE in nephrotoxicity induced by several special medicines such as cisplatin, doxorubicin, cyclosporine, gentamycin, methotrexate, and other causes leading to oxidative renal injury, namely, I/R models and senility.

Indexed as

Acute Kidney InjuryAnimalsAntineoplastic AgentsAntioxidantsCaffeic AcidsHumansOxidative StressPhenylethyl AlcoholAntineoplastic AgentsAntioxidantscaffeic acid phenethyl esterCaffeic AcidsPhenylethyl Alcohol

Identifiers

PMID25003138
PMCPMC4065767
OpenAlexW2167144363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.