ArticleBioMed research international2014
Erythrophagocytosis in Entamoeba histolytica and Entamoeba dispar: a comparative study.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Antiamoebic drugs for treating amoebic colitis.The Cochrane database of systematic reviews · 2019Pooled it
- A Cross-Sectional Study ofBioMed research international · 2019Trial
- Low-Iron Bovine Lactoferrin Affects Adhesion, Erythrophagocytosis, Cytotoxicity, and Proteolytic Activity inInternational journal of molecular sciences · 2026Article
- Article
- EhVps23, an ESCRT-I Member, Is a Key Factor in Secretion, Motility, Phagocytosis and Tissue Invasion byFrontiers in cellular and infection microbiology · 2022Article
- Protein Phosphatase PP2C Identification inBioMed research international · 2021Article
- Acetylcholine UpregulatesFrontiers in cellular and infection microbiology · 2020Article
- Functional Characterization of an Interferon Gamma Receptor-Like Protein on Entamoeba histolytica.Infection and immunity · 2019Article
- A Calcium/Cation Exchanger Participates in the Programmed Cell Death andFrontiers in cellular and infection microbiology · 2018Article
- The Monomeric GTPase Rab35 Regulates Phagocytic Cup Formation and Phagosomal Maturation inThe Journal of biological chemistry · 2017Article
- Comparison of hemolytic activity of the intermediate subunit of Entamoeba histolytica and Entamoeba dispar lectins.PloS one · 2017Article
- EhNPC1 and EhNPC2 Proteins Participate in Trafficking of Exogenous Cholesterol in Entamoeba histolytica Trophozoites: Relevance for Phagocytosis.PLoS pathogens · 2016Article
- Antiamoebic Activity of Adenophyllum aurantium (L.) Strother and Its Effect on the Actin Cytoskeleton of Entamoeba histolytica.Frontiers in pharmacology · 2016Article
- Analysis of the Bacterial Diversity in Liver Abscess: Differences Between Pyogenic and Amebic Abscesses.The American journal of tropical medicine and hygiene · 2016Article
- Iron-Binding Protein Degradation by Cysteine Proteases of Naegleria fowleri.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Entamoeba histolytica is the causative agent of human intestinal and liver amebiasis. The extraordinary phagocytic activity of E. histolytica trophozoites has been accepted as one of the virulence mechanisms responsible for their invasive capacity. The recognition of the noninvasive Entamoeba dispar as a different species has raised the question as to whether the lack of pathogenic potential of this ameba correlates with a limited phagocytic capacity. We have therefore compared the process of erythrophagocytosis in both species by means of light and video microscopy, hemoglobin measurement, and the estimation of reactive oxygen species (ROS). In the present study, we confirmed that E. dispar has lower erythrophagocytic capacity. We also observed by video microscopy a new event of erythrocyte opsonization-like in both species, being more characteristic in E. histolytica. Moreover, E. dispar showed a lower capacity to produce ROS compared with the invasive species and also showed a large population of amoebae that did not engulf any erythrocyte over time. Our results demonstrate that E. histolytica has a higher phagocytic capacity than E. dispar, including a higher rate of production of ROS in the course of ingesting red blood cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.