ArticleBioMed research international2014
Evaluation of human amniotic membrane as a wound dressing for split-thickness skin-graft donor sites.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Human Amniotic Membrane: A New Option for Graft Donor Sites - Systematic Review and Meta-analysis.International wound journal · 2020Pooled it
- The effects of Alkanna tinctoria Tausch on split-thickness skin graft donor site management: a randomized, blinded placebo-controlled trial.BMC complementary and alternative medicine · 2017Trial
- Dynamic optical coherence tomography for imaging acute wound healing.International wound journal · 2024Article
- Injectable multifunctional hydrogel containing Sphingosine 1-phosphate and human acellular amniotic membrane for skin wound healing.Iranian journal of basic medical sciences · 2024Article
- A Prospective Multicenter Study of a Weekly Application Regimen of Viable Human Amnion Membrane Allograft in the Management of Nonhealing Diabetic Foot Ulcers.Plastic and reconstructive surgery. Global open · 2023Article
- The importance of inflammation control for the treatment of chronic diabetic wounds.International wound journal · 2023Review
- Outcome of Application of Cryopreserved Amniotic Membrane Grafts in the Treatment of Chronic Nonhealing Wounds of Different Origins in Polymorbid Patients: A Prospective Multicenter Study.Bioengineering (Basel, Switzerland) · 2023Article
- Investigating the joint application of negative pressure wound treatment and tissue therapy for chronic wounds in patients with diabetes.Journal of medicine and life · 2023Article
- Quantification of Analgesic and Anti-Inflammatory Lipid Mediators in Long-Term Cryopreserved and Freeze-Dried Preserved Human Amniotic Membrane.Bioengineering (Basel, Switzerland) · 2023Article
- Preparation of human amniotic membrane for transplantation in different application areas.Frontiers in transplantation · 2023Review
- A comprehensive review on methods for promotion of mechanical features and biodegradation rate in amniotic membrane scaffolds.Journal of materials science. Materials in medicine · 2022Review
- Clinical application of both amniotic membranes and adipose derived mesenchymal stem cells in a cat with a large skin defect.Veterinarni medicina · 2022Article
- Surgical Application of Human Amniotic Membrane and Amnion-Chorion Membrane in the Oral Cavity and Efficacy Evaluation: Corollary With Ophthalmological and Wound Healing Experiences.Frontiers in bioengineering and biotechnology · 2021Review
- Human Amniotic Epithelial Cells Secretome: Components, Bioactivity, and Challenges.Frontiers in medicine · 2021Review
- Development of Contact Lens-Shaped Crosslinked Amniotic Membranes for Sutureless Fixation in the Treatment of Ocular Surface Diseases.Translational vision science & technology · 2020Article
- The role of labeled cell therapy with and without scaffold in early excision burn wounds in a rat animal model.Iranian journal of basic medical sciences · 2020Article
- Gamma-treated placental amniotic membrane allograft as the adjuvant treatment of unresponsive diabetic ulcer of the foot.International journal of surgery case reports · 2020Article
- Evaluation of Tissue-engineered Skin on Base of Human Amniotic Membrane for Wound Healing.Plastic and reconstructive surgery. Global open · 2019Article
- Bladder Reconstruction with Human Amniotic Membrane in a Xenograft Rat Model: A Preclinical Study.International journal of medical sciences · 2017Article
- Aseptically Processed Placental Membrane Improves Healing of Diabetic Foot Ulcerations: Prospective, Randomized Clinical Trial.Plastic and reconstructive surgery. Global open · 2016Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human amniotic membrane (HAM) has been used as a biomaterial in various surgical procedures and exceeds some qualities of common materials. We evaluated HAM as wound dressing for split-thickness skin-graft (STSG) donor sites in a swine model (Part A) and a clinical trial (Part B). Part A: STSG donor sites in 4 piglets were treated with HAM or a clinically used conventional polyurethane (PU) foil (n = 8 each). Biopsies were taken on days 5, 7, 10, 20, 40, and 60 and investigated immunohistochemically for alpha-smooth muscle actin (αSMA: wound contraction marker), von Willebrand factor (vWF: angiogenesis), Ki-67 (cell proliferation), and laminin (basement membrane integrity). Part B: STSG donor sites in 45 adult patients (16 female/29 male) were treated with HAM covered by PU foam, solely by PU foam, or PU foil/paraffin gauze (n = 15 each). Part A revealed no difference in the rate of wound closure between groups. HAM showed improved esthetic results and inhibitory effects on cicatrization. Angioneogenesis was reduced, and basement membrane formation was accelerated in HAM group. Part B: no difference in re-epithelialization/infection rate was found. HAM caused less ichor exudation and less pruritus. HAM has no relevant advantage over conventional dressings but might be a cost-effective alternative.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.