Evidence map›Paper›PMID 25003032›Full record

ArticleNeuroImage. Clinical2014

Localized abnormalities in the cingulum bundle in patients with schizophrenia: a Diffusion Tensor tractography study.

Thomas J Whitford, Sun Woo Lee, Jungsu S Oh, Rodrigo de Luis-Garcia, Peter Savadjiev, Jorge L Alvarado, Carl-Fredrik Westin, Margaret Niznikiewicz, Paul G Nestor, Robert W McCarley and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

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  16. White matter microstructure in schizophrenia patients with a history of violence.European archives of psychiatry and clinical neuroscience · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Thomas J WhitfordSchool of Psychology, University of New South Wales, Sydney, NSW, Australia ; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sun Woo LeePsychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA ; Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, South Korea.
Jungsu S OhPsychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA ; Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Rodrigo de Luis-GarciaLaboratory of Mathematics in Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA ; Laboratorio de Procesado de Imagen, Universidad de Valladolid, Spain.
Peter SavadjievPsychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA ; Laboratory of Mathematics in Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jorge L AlvaradoPsychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Carl-Fredrik WestinLaboratory of Mathematics in Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Margaret NiznikiewiczClinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston Veterans Affairs Healthcare System, Brockton Division, Brockton, MA, USA and Harvard Medical School, Boston, MA, USA.
Paul G NestorClinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston Veterans Affairs Healthcare System, Brockton Division, Brockton, MA, USA and Harvard Medical School, Boston, MA, USA ; Boston Veterans Affairs Healthcare System, Brockton Division, Brockton, MA, USA ; Department of Psychology, University of Massachusetts, Boston, MA, USA.
Robert W McCarleyClinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston Veterans Affairs Healthcare System, Brockton Division, Brockton, MA, USA and Harvard Medical School, Boston, MA, USA.
Marek KubickiPsychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Martha E ShentonPsychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA ; Boston Veterans Affairs Healthcare System, Brockton Division, Brockton, MA, USA.
Harvard University · USBrigham and Women's Hospital · USSignature Healthcare Brockton Hospital · USUlsan College · KRUniversidad de Valladolid · ES

Funding

Washington University ConsoritumU54EB005149 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON · 2004 to 2013
$39.3M
Vulnerability to Progression SchizophreniaP50MH080272 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHENTON, MARTHA E. · 2007 to 2011
$9.9M
Novel DT-MRI Analyses of White Matter in SchizophreniaR01MH074794 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI WESTIN, CARL-FREDRIK · 2007 to 2021
$9.6M
NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIAR01MH040799 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MCCARLEY, ROBERT W · 1986 to 2011
$6.5M
Clinical Symptons &Brain Abnormalities in SchizophreniaK05MH070047 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SHENTON, MARTHA E. · 2004 to 2008
$581k
NIBIB NIH HHS U54 EB005149NIMH NIH HHS K05 MH070047NIMH NIH HHS P50 MH 080272NIMH NIH HHS P50 MH080272NIMH NIH HHS R01 MH040799NIMH NIH HHS R01 MH074794NIMH NIH HHS R01MH074794NIMH NIH HHS R01 MH 50747
6 · The paper itself

Abstract

The cingulum bundle (CB) connects gray matter structures of the limbic system and as such has been implicated in the etiology of schizophrenia. There is growing evidence to suggest that the CB is actually comprised of a conglomeration of discrete sub-connections. The present study aimed to use Diffusion Tensor tractography to subdivide the CB into its constituent sub-connections, and to investigate the structural integrity of these sub-connections in patients with schizophrenia and matched healthy controls. Diffusion Tensor Imaging scans were acquired from 24 patients diagnosed with chronic schizophrenia and 26 matched healthy controls. Deterministic tractography was used in conjunction with FreeSurfer-based regions-of-interest to subdivide the CB into 5 sub-connections (I1 to I5). The patients with schizophrenia exhibited subnormal levels of FA in two cingulum sub-connections, specifically the fibers connecting the rostral and caudal anterior cingulate gyrus (I1) and the fibers connecting the isthmus of the cingulate with the parahippocampal cortex (I4). Furthermore, while FA in the I1 sub-connection was correlated with the severity of patients' positive symptoms (specifically hallucinations and delusions), FA in the I4 sub-connection was correlated with the severity of patients' negative symptoms (specifically affective flattening and anhedonia/asociality). These results support the notion that the CB is a conglomeration of structurally interconnected yet functionally distinct sub-connections, of which only a subset are abnormal in patients with schizophrenia. Furthermore, while acknowledging the fact that the present study only investigated the CB, these results suggest that the positive and negative symptoms of schizophrenia may have distinct neurobiological underpinnings.

Indexed as

AdultAnisotropyBrain MappingDiffusion Tensor ImagingGyrus CinguliHumansImage Processing, Computer-AssistedMaleMiddle AgedSchizophreniaCingulate gyrusCingulum bundleDiffusion Tensor ImagingDTIFractional AnisotropySchizophrenia

Identifiers

PMID25003032
PMCPMC4081981
OpenAlexW2151593200

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.