ArticleNeuroImage. Clinical2014
Changes in MEG resting-state networks are related to cognitive decline in type 1 diabetes mellitus patients.
Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Type-1 Diabetes Impacts Brain Microstructure and Anatomical Associations in Young and Well-Controlled Individuals.Brain topography · 2025Article
- Brain Functional Topology Alteration in Right Lateral Occipital Cortex Is Associated With Upper Extremity Motor Recovery.Frontiers in neurology · 2022Article
- Depletion of acetate-producing bacteria from the gut microbiota facilitates cognitive impairment through the gut-brain neural mechanism in diabetic mice.Microbiome · 2021Article
- Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2020Observational
- Resting-State Functional Connectivity Magnetic Resonance Imaging and Outcome After Acute Stroke.Stroke · 2018Article
- Assessment and elimination of the effects of head movement on MEG resting-state measures of oscillatory brain activity.NeuroImage · 2017Article
- Altered eigenvector centrality is related to local resting-state network functional connectivity in patients with longstanding type 1 diabetes mellitus.Human brain mapping · 2017Article
- Resting-state functional MR imaging shed insights into the brain of diabetes.Metabolic brain disease · 2016Review
- Disrupted subject-specific gray matter network properties and cognitive dysfunction in type 1 diabetes patients with and without proliferative retinopathy.Human brain mapping · 2016Article
- Short and long term neuro-behavioral alterations in type 1 diabetes mellitus pediatric population.World journal of diabetes · 2015Review
- Impairment of functional integration of the default mode network correlates with cognitive outcome at three months after stroke.Human brain mapping · 2015Article
- Age of Childhood Onset in Type 1 Diabetes and Functional Brain Connectivity in Midlife.Psychosomatic medicineArticle
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9 authors.
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Abstract
objectiveIntegrity of resting-state functional brain networks (RSNs) is important for proper cognitive functioning. In type 1 diabetes mellitus (T1DM) cognitive decrements are commonly observed, possibly due to alterations in RSNs, which may vary according to microvascular complication status. Thus, we tested the hypothesis that functional connectivity in RSNs differs according to clinical status and correlates with cognition in T1DM patients, using an unbiased approach with high spatio-temporal resolution functional network.
methodsResting-state magnetoencephalographic (MEG) data for T1DM patients with (n = 42) and without (n = 41) microvascular complications and 33 healthy participants were recorded. MEG time-series at source level were reconstructed using a recently developed atlas-based beamformer. Functional connectivity within classical frequency bands, estimated by the phase lag index (PLI), was calculated within eight commonly found RSNs. Neuropsychological tests were used to assess cognitive performance, and the relation with RSNs was evaluated.
resultsSignificant differences in terms of RSN functional connectivity between the three groups were observed in the lower alpha band, in the default-mode (DMN), executive control (ECN) and sensorimotor (SMN) RSNs. T1DM patients with microvascular complications showed the weakest functional connectivity in these networks relative to the other groups. For DMN, functional connectivity was higher in patients without microangiopathy relative to controls (all p < 0.05). General cognitive performance for both patient groups was worse compared with healthy controls. Lower DMN alpha band functional connectivity correlated with poorer general cognitive ability in patients with microvascular complications. DISCUSSION: Altered RSN functional connectivity was found in T1DM patients depending on clinical status. Lower DMN functional connectivity was related to poorer cognitive functioning. These results indicate that functional connectivity may play a key role in T1DM-related cognitive dysfunction.
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