ArticleFrontiers in physiology2014
Altered oscillatory cerebral blood flow velocity and autoregulation in postural tachycardia syndrome.
Article in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Mapping cerebral blood flow in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and orthostatic intolerance: insights from a systematic review.Journal of translational medicine · 2025Pooled it
- Heart rate and heart rate variability comparison between postural orthostatic tachycardia syndrome versus healthy participants; a systematic review and meta-analysis.BMC cardiovascular disorders · 2019Pooled it
- Cerebral Blood Flow in Orthostatic Intolerance.Journal of the American Heart Association · 2025Review
- Sympathetic vasomotion as an early marker of hemorrhage.Frontiers in physiology · 2025Article
- The relationship between cardiovagal baroreflex and cerebral autoregulation in postural orthostatic tachycardia disorder using advanced cross-correlation function.Scientific reports · 2024Article
- Phenylephrine alters phase synchronization between cerebral blood velocity and blood pressure in ME/CFS with orthostatic intolerance.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Postural orthostatic tachycardia syndrome explained using a baroreflex response model.Journal of the Royal Society, Interface · 2022Article
- Supine Parasympathetic Withdrawal and Upright Sympathetic Activation Underly Abnormalities of the Baroreflex in Postural Tachycardia Syndrome: Effects of Pyridostigmine and Digoxin.Hypertension (Dallas, Tex. : 1979) · 2021Article
- The Acute Effects of Time-Varying Caloric Vestibular Stimulation as Assessed With fMRI.Frontiers in systems neuroscience · 2021Article
- Postural tachycardia syndrome - Diagnosis, physiology, and prognosis.Autonomic neuroscience : basic & clinical · 2018Review
- Article
- Intracranial compliance is associated with symptoms of orthostatic intolerance in chronic fatigue syndrome.PloS one · 2018Article
- Oscillatory lower body negative pressure impairs working memory task-related functional hyperemia in healthy volunteers.American journal of physiology. Heart and circulatory physiology · 2017Article
- Oscillatory lower body negative pressure impairs task related functional hyperemia in healthy volunteers.American journal of physiology. Heart and circulatory physiology · 2016Article
- Orthostatic Cerebral Hypoperfusion Syndrome.Frontiers in aging neuroscience · 2016Article
- Oscillatory cerebral blood flow is associated with impaired neurocognition and functional hyperemia in postural tachycardia syndrome during graded tilt.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Neuro-humoral control during orthostasis in health and disease.Frontiers in physiology · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Decreased upright cerebral blood flow (CBF) with hyperpnea and hypocapnia is seen in a minority of patients with postural tachycardia syndrome (POTS). More often, CBF is not decreased despite upright neurocognitive dysfunction. This may result from time-dependent changes in CBF. We hypothesized that increased oscillations in CBF occurs in POTS (N = 12) compared to healthy controls (N = 9), and tested by measuring CBF velocity (CBFv) by transcranial Doppler ultrasound of the middle cerebral artery, mean arterial pressure (MAP) and related parameters, supine and during 70° upright tilt. Autospectra for mean CBFv and MAP, and transfer function analysis were obtained over the frequency range of 0.0078-0.4 Hz. Upright HR was increased in POTS (125 ± 8 vs. 86 ± 2 bpm), as was diastolic BP (74 ± 3 vs. 65 ± 3 mmHg) compared to control, while peripheral resistance, cardiac output, and mean CBFv increased similarly with tilt. Upright BP variability (BPV), low frequency (LF) power (0.04-0.13 Hz), and peak frequency of BPV were increased in POTS (24.3 ± 4.1, and 18.4 ± 4.1 mmHg(2)/Hz at 0.091 Hz vs. 11.8 ± 3.3, and 8.8 ± 2 mmHg(2)/Hz c at 0.071 Hz), as was upright overall CBFv variability, low frequency power and peak frequency of CBFv variability (29.3 ± 4.7, and 22.1 ± 2.7 [cm/s](2)/Hz at.092 Hz vs. 14.7 ± 2.6, and 6.7 ± 1.2 [cm/s](2)/Hz at 0.077Hz). Autospectra were sharply peaked in POTS. LF phase was decreased in POTS (-14 ± 4 vs. -25 ± 10 degrees) while upright. LF gain was increased (1.51 ± 0.09 vs. 0.86 ± 0.12 [cm/s]/ mmHg) while coherence was increased (0.96 ± 0.01 vs. 0.80 ± 0.04). Increased oscillatory BP in upright POTS patients is closely coupled to oscillatory CBFv over a narrow bandwidth corresponding to the Mayer wave frequency. Therefore combined increased oscillatory BP and increased LF gain markedly increases CBFv oscillations in a narrow bandwidth. This close coupling of CBF to MAP indicates impaired cerebral autoregulation that may underlie upright neurocognitive dysfunction in POTS.
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Registered trials
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