Evidence map›Paper›PMID 25002814›Full record

ArticleBioinformatics and biology insights2014

DOR - a Database of Olfactory Receptors - Integrated Repository for Sequence and Secondary Structural Information of Olfactory Receptors in Selected Eukaryotic Genomes.

Balasubramanian Nagarathnam, Snehal D Karpe, Krishnan Harini, Kannan Sankar, Mohammed Iftekhar, Durairaj Rajesh, Sadasivam Giji, Govidaraju Archunan, Veluchamy Balakrishnan, M Michael Gromiha and 3 more

Open access · goldAbstract read
In one paragraph

Article in Bioinformatics and biology insights, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Balasubramanian NagarathnamNational Center for Biological Sciences (TIFR), Bangalore, India.
Snehal D KarpeNational Center for Biological Sciences (TIFR), Bangalore, India.
Krishnan HariniNational Center for Biological Sciences (TIFR), Bangalore, India.
Kannan SankarBirla Institute of Technology and Science, Pilani, India. ; Presently in: Bioinformatics and Computational Biology Program, Iowa State University, Ames, IA, USA.
Mohammed IftekharNational Center for Biological Sciences (TIFR), Bangalore, India.
Durairaj RajeshDepartment of Animal Sciences, Bharathidasan University, Tiruchirapalli, Tamil Nadu, India.
Sadasivam GijiNational Center for Biological Sciences (TIFR), Bangalore, India.
Govidaraju ArchunanDepartment of Animal Sciences, Bharathidasan University, Tiruchirapalli, Tamil Nadu, India.
Veluchamy BalakrishnanDepartment of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India.
M Michael GromihaDepartment of Biotechnology, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India.
Wataru NemotoCurrent Address: Division of Life Science and Engineering, School of Science and Engineering, Tokyo Denki University, Ishizaka, Hatoyama-cho, Hiki-gun, Saitama, 350-0394, Japan.
Kazhuhiko FukuiMolecular Profiling Research Center for Drug Discover, National Institute of Advanced Industrial Science and Technology, Aomi, Koto-ku,Tokyo, Japan.
Ramanathan SowdhaminiNational Center for Biological Sciences (TIFR), Bangalore, India.
Birla Institute of Technology and Science, Pilani · INIndian Institute of Technology Madras · INTokyo Denki University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Olfaction is the response to odors and is mediated by a class of membrane-bound proteins called olfactory receptors (ORs). An understanding of these receptors serves as a good model for basic signal transduction mechanisms and also provides important clues for the strategies adopted by organisms for their ultimate survival using chemosensory perception in search of food or defense against predators. Prior research on cross-genome phylogenetic analyses from our group motivated the addressal of conserved evolutionary trends, clustering, and ortholog prediction of ORs. The database of olfactory receptors (DOR) is a repository that provides sequence and structural information on ORs of selected organisms (such as Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, Mus musculus, and Homo sapiens). Users can download OR sequences, study predicted membrane topology, and obtain cross-genome sequence alignments and phylogeny, including three-dimensional (3D) structural models of 100 selected ORs and their predicted dimer interfaces. The database can be accessed from http://caps.ncbs.res.in/DOR. Such a database should be helpful in designing experiments on point mutations to probe into the possible dimerization modes of ORs and to even understand the evolutionary changes between different receptors.

Indexed as

insect olfactory systemmembrane proteinsodor perceptionolfaction

Identifiers

PMID25002814
PMCPMC4069036
OpenAlexW2077934671

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.