ArticleMediators of inflammation2014
Treadmill training increases SIRT-1 and PGC-1 α protein levels and AMPK phosphorylation in quadriceps of middle-aged rats in an intensity-dependent manner.
Article in Mediators of inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Advances in statin adverse reactions and the potential mechanisms: A systematic review.Journal of advanced research · 2025Pooled it
- Metformin lotion as a novel approach to prevent tendinopathy induced by mechanical overuse.Scientific reports · 2025Article
- Paternal Exercise Improves the Metabolic Health of Offspring via Epigenetic Modulation of the Germline.International journal of molecular sciences · 2021Article
- The effects of different types of aquatic exercise training interventions on a high-fructose diet-fed mice.International journal of medical sciences · 2021Article
- Exercise-Induced Neuroprotection in the 6-Hydroxydopamine Parkinson's Disease Model.Neurotoxicity research · 2020Article
- Dipeptidyl peptidase-4 inhibitors and aerobic exercise synergistically protect against liver injury in ovariectomized rats.Physiological reports · 2019Article
- Effects of Preventive Treadmill Exercise on the Recovery of Metabolic and Mitochondrial Factors in the 6-Hydroxydopamine Rat Model of Parkinson's Disease.Neurotoxicity research · 2019Article
- Effects of detraining and retraining on muscle energy-sensing network and meteorin-like levels in obese mice.Lipids in health and disease · 2018Article
- Treadmill Exercise Attenuates α-Synuclein Levels by Promoting Mitochondrial Function and Autophagy Possibly via SIRT1 in the Chronic MPTP/P-Induced Mouse Model of Parkinson's Disease.Neurotoxicity research · 2017Article
- Effect of glycosides ofNeural regeneration research · 2017Article
- Fructose Consumption in the Development of Obesity and the Effects of Different Protocols of Physical Exercise on the Hepatic Metabolism.Nutrients · 2017Review
- Voluntary Running Attenuates Metabolic Dysfunction in Ovariectomized Low-Fit Rats.Medicine and science in sports and exercise · 2017Article
- SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients.International journal of chronic obstructive pulmonary disease · 2017Observational
- The Combination of Physical Exercise with Muscle-Directed Antioxidants to Counteract Sarcopenia: A Biomedical Rationale for Pleiotropic Treatment with Creatine and Coenzyme Q10.Oxidative medicine and cellular longevity · 2017Review
- Training for skeletal muscle capillarization: a Janus-faced role of exercise intensity?European journal of applied physiology · 2016Article
- Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics.Oxidative medicine and cellular longevity · 2015Review
- Exercise-induced PGC-1α transcriptional factors in skeletal muscle.Integrative medicine research · 2014Review
- Retracted: Treadmill Training Increases SIRT-1 and PGC-1Mediators of inflammationArticle
Corrections and comments
- Retraction · 2017-10-16Duplication of/in Image · Euphemisms for Duplication ·
- Retracted
Authors and funding
15 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigated the effects of running at 0.8 or 1.2 km/h on inflammatory proteins (i.e., protein levels of TNF- α , IL-1 β , and NF- κ B) and metabolic proteins (i.e., protein levels of SIRT-1 and PGC-1 α , and AMPK phosphorylation) in quadriceps of rats. Male Wistar rats at 3 (young) and 18 months (middle-aged rats) of age were divided into nonexercised (NE) and exercised at 0.8 or 1.2 km/h. The rats were trained on treadmill, 50 min per day, 5 days per week, during 8 weeks. Forty-eight hours after the last training session, muscles were removed, homogenized, and analyzed using biochemical and western blot techniques. Our results showed that: (a) running at 0.8 km/h decreased the inflammatory proteins and increased the metabolic proteins compared with NE rats; (b) these responses were lower for the inflammatory proteins and higher for the metabolic proteins in young rats compared with middle-aged rats; (c) running at 1.2 km/h decreased the inflammatory proteins and increased the metabolic proteins compared with 0.8 km/h; (d) these responses were similar between young and middle-aged rats when trained at 1.2 km. In summary, the age-related increases in inflammatory proteins, and the age-related declines in metabolic proteins can be reversed and largely improved by treadmill training.
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