Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2014
Safety and efficacy of aerobic training in patients with cancer who have heart failure: an analysis of the HF-ACTION randomized trial.
Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Exercise-based interventions for preventing and treating cancer therapy-related cardiovascular toxicity: a systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Effects of Physical Exercise and the use of Doxorubicin on Cardiac Function in Rodents: A Systematic Review and Meta-Analysis.Current cardiology reviews · 2025Pooled it
- Exercise-based cardiac rehabilitation for adults with heart failure.The Cochrane database of systematic reviews · 2024Pooled it
- Pooled it
- Attention to principles of exercise training: an updated systematic review of randomized controlled trials in cancers other than breast and prostate.BMC cancer · 2021Pooled it
- Aerobic physical exercise for adult patients with haematological malignancies.The Cochrane database of systematic reviews · 2019Pooled it
- Exercise-based cardiac rehabilitation for adults with heart failure.The Cochrane database of systematic reviews · 2019Pooled it
- Interventions for promoting habitual exercise in people living with and beyond cancer.The Cochrane database of systematic reviews · 2018Pooled it
- Efficacy of Exercise Therapy on Cardiorespiratory Fitness in Patients With Cancer: A Systematic Review and Meta-Analysis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Pooled it
- Effect of Exercise on Mortality and Recurrence in Patients With Cancer: A Systematic Review and Meta-Analysis.Integrative cancer therapiesPooled it
- Feasibility and Outcomes of an Exercise Intervention for Chemotherapy-Induced Heart Failure.Journal of cardiopulmonary rehabilitation and prevention · 2019Trial
- Methods for assessing exercise fidelity in unsupervised home-based cardiovascular rehabilitation: a scoping review.BMC sports science, medicine & rehabilitation · 2025Article
- Relevance of Cardiovascular Exercise in Cancer and Cancer Therapy-Related Cardiac Dysfunction.Current heart failure reports · 2024Review
- Incorporating Exercise Training into Cardio-Oncology Care: Current Evidence and Opportunities:JACC. CardioOncology · 2023Review
- Characteristics and research status among clinical trials in cardio-oncology by bibliometric and visualized analysis.Cancer medicine · 2023Review
- Cardio-Oncology Rehabilitation-Present and Future Perspectives.Life (Basel, Switzerland) · 2022Review
- Review
- Mechanism and prevention strategy of a bidirectional relationship between heart failure and cancer (Review).Experimental and therapeutic medicine · 2021Review
- Exercise, cancer and cardiovascular disease: what should clinicians advise?Cardiovascular endocrinology & metabolism · 2021Review
- Oncology and Cardiac Rehabilitation: An Underrated Relationship.Journal of clinical medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
purposeTo investigate the efficacy and safety of aerobic training (AT) in patients with cancer with medically stable heart failure (HF). PATIENTS AND
methodsA retrospective analysis of 90 patients with cancer who have HF and who were randomly assigned to AT (n = 47) or guideline-based usual care (UC; n = 43) was performed. AT consisted of three supervised sessions per week at 20 to 45 minutes per session at 60% to 70% of heart rate reserve for 12 weeks followed by home-based sessions for 4 to 12 months. The primary end point was all-cause mortality and hospitalization. Secondary end points were other clinical events, safety, and change in exercise capacity (VO(2peak)) and health-related quality of life (HRQOL).
resultsMedian follow-up was 35 months. In intention-to-treat (ITT) analyses, all-cause mortality or hospitalization at 2 years was 74% in the AT group compared with 67% in the UC group (adjusted hazard ratio [HR], 1.11; 95% CI, 0.69 to 1.77; P = .676). The incidence of cardiovascular mortality or cardiovascular hospitalization was significantly higher in the AT group compared with the UC group (41% v 67%; adjusted HR, 1.94; 95% CI, 1.12 to 3.16; P = .017). There were no differences in any VO(2peak) or HRQOL end points. In post hoc analyses based on adherence to AT, all-cause mortality and hospitalization was 66% in adherent patients (≥ 90 minutes per week) compared with 84% in nonadherent patients (< 90 minutes per week).
conclusionIn ITT analyses, AT did not improve clinical outcomes in patients with cancer who had HF. Post hoc analyses suggested that patients not capable of adhering to the planned AT prescription may be at increased risk of clinical events.
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