Evidence map›Paper›PMID 25002461›Full record

ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2014

Deletion of C-reactive protein ameliorates experimental cerebral malaria?

Alexander J Szalai, Scott R Barnum, Theresa N Ramos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei.Mammalian genome : official journal of the International Mammalian Genome Society · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexander J SzalaiDepartment of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Scott R BarnumDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA sbarnum@uab.edu.
Theresa N RamosDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

Funding

IMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYT32AI007051 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Laurie Ellen Harrington · 1985 to 2026
$13.1M
C-reactive protein in acute kidney injuryR01DK099092 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SZALAI, ALEXANDER J · 2014 to 2017
$1.3M
The role of the terminal complement pathway in experimental cerebral malaria.F31NS077811 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RAMOS, THERESA N · 2012 to 2012
$24k
NIAID NIH HHS T32 AI007051NIAID NIH HHS T32 AI07051NIDDK NIH HHS R01 DK099092NINDS NIH HHS F31 NS077811
6 · The paper itself

Abstract

backgroundC-reactive protein (CRP) level correlates with parasitemia and severity of malaria, but whether this reflects causality remains unknown.

methodsUsing CRP-transgenic and CRP-deficient mice we compared the onset and severity of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA).

resultsCRP-deficient mice were most resistant to ECM.

conclusionsCRP might contribute to the development of cerebral malaria, rather than protect against it.

Indexed as

AnimalsCarrier ProteinsC-Reactive ProteinMalaria, CerebralMiceMice, Inbred C57BLPlasmodium bergheiSequence DeletionSeverity of Illness IndexUp-RegulationCarrier ProteinsC-Reactive ProteinAcute phase proteinCerebral malariaC-reactive proteinParasitemia

Identifiers

PMID25002461
PMCPMC4192040

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.