ArticleApplied and environmental microbiology2014
Role of oxidative stress in Sclerotial differentiation and aflatoxin B1 biosynthesis in Aspergillus flavus.
Article in Applied and environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Dietary mycotoxin toxicity inAdvances in neurotoxicology · 2026Article
- Role of theToxins · 2025Article
- Application of chitosan-based nanomatrix enriched with Melaleuca alternifolia essential oil against the growth of storage fungi and aflatoxin BBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Review
- Assessing the efficacy of nanofabricated plant-based antifungal formulation against the growth and zearalenone toxin production by Fusarium graminearum.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Transcriptomic profiling of adding cobalt chloride to improve dendrobine-type total alkaloid production.Applied microbiology and biotechnology · 2024Article
- Drug-Loaded Mesoporous Polydopamine Nanoparticles in Chitosan Hydrogels Enable Myocardial Infarction Repair through ROS Scavenging and Inhibition of Apoptosis.ACS applied materials & interfaces · 2024Article
- Inhibition of Fungal Growth and Aflatoxin BFoods (Basel, Switzerland) · 2023Article
- Integrated metabolomics and lipidomics analyses suggest the temperature-dependent lipid desaturation promotes aflatoxin biosynthesis inFrontiers in microbiology · 2023Article
- Immunomodulatory effects of aflatoxin B1 (AFB1) and the use of natural products to ameliorate its immunotoxic effects: A review.Open research Africa · 2023Review
- Superoxide Initiates the Hyphal Differentiation to Microsclerotia Formation ofMicrobiology spectrum · 2022Article
- The Solvent Dimethyl Sulfoxide Affects Physiology, Transcriptome and Secondary Metabolism ofJournal of fungi (Basel, Switzerland) · 2021Article
- Article
- Influence of HToxins · 2021Article
- Aflatoxin Biosynthesis, Genetic Regulation, Toxicity, and Control Strategies: A Review.Journal of fungi (Basel, Switzerland) · 2021Review
- Synthetic antimicrobial agents inhibit aflatoxin production.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Article
- Antifungal Effects of Fusion Puroindoline B on the Surface and Intracellular Environment of Aspergillus flavus.Probiotics and antimicrobial proteins · 2021Article
- Sisters in structure but different in character, some benzaldehyde and cinnamaldehyde derivatives differentially tune Aspergillus flavus secondary metabolism.Scientific reports · 2020Article
- Article
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4 authors.
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Abstract
We show here that oxidative stress is involved in both sclerotial differentiation (SD) and aflatoxin B1 biosynthesis in Aspergillus flavus. Specifically, we observed that (i) oxidative stress regulates SD, as implied by its inhibition by antioxidant modulators of reactive oxygen species and thiol redox state, and that (ii) aflatoxin B1 biosynthesis and SD are comodulated by oxidative stress. However, aflatoxin B1 biosynthesis is inhibited by lower stress levels compared to SD, as shown by comparison to undifferentiated A. flavus. These same oxidative stress levels also characterize a mutant A. flavus strain, lacking the global regulatory gene veA. This mutant is unable to produce sclerotia and aflatoxin B1. (iii) Further, we show that hydrogen peroxide is the main modulator of A. flavus SD, as shown by its inhibition by both an irreversible inhibitor of catalase activity and a mimetic of superoxide dismutase activity. On the other hand, aflatoxin B1 biosynthesis is controlled by a wider array of oxidative stress factors, such as lipid hydroperoxide, superoxide, and hydroxyl and thiyl radicals.
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