Trial reportClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2015
Startling acoustic stimuli can evoke fast hand extension movements in stroke survivors.
Trial report in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- What Is the StartReact Effect?Acta physiologica (Oxford, England) · 2026Review
- Motor planning, initiation and execution of shoulder abduction against gravity: Evidence from startReact.PloS one · 2026Article
- Startling acoustic stimuli hasten reflexive choice reaching tasks by enhancing, but not changing the timing of, express visuomotor responses.The Journal of physiology · 2025Article
- Association of a kinematic measure of upper limb reaching and StartReact in chronic hemiparetic stroke.Experimental brain research · 2025Article
- Effects of asymmetrical postural demands on sternocleidomastoid reflex in the startReact paradigm.Frontiers in human neuroscience · 2025Article
- The interplay of perceptual processing demands and practice in modulating voluntary and involuntary motor responses.Psychophysiology · 2024Article
- An intense electrical stimulus can elicit a StartReact effect but with decreased incidence and later onset of the startle reflex.Experimental brain research · 2024Article
- Influence of task complexity on movement planning and release after stroke: insights from startReact.Experimental brain research · 2022Article
- Ipsilateral motor pathways to the lower limb after stroke: Insights and opportunities.Journal of neuroscience research · 2021Review
- Does exposure to startle impact voluntary reaching movements in individuals with severe-to-moderate stroke?Experimental brain research · 2021Article
- StartReact increases the probability of muscle activity and distance in severe/moderate stroke survivors during two-dimensional reaching task.Experimental brain research · 2020Article
- Stretch reflex excitability in contralateral limbs of stroke survivors is higher than in matched controls.Journal of neuroengineering and rehabilitation · 2019Article
- Stabilizing stretch reflexes are modulated independently from the rapid release of perturbation-triggered motor plans.Scientific reports · 2019Article
- Differences between flexion and extension synergy-driven coupling at the elbow, wrist, and fingers of individuals with chronic hemiparetic stroke.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2019Article
- Impaired posture, movement preparation, and execution during both paretic and nonparetic reaching following stroke.Journal of neurophysiology · 2019Article
- Startle evokes nearly identical movements in multi-jointed, two-dimensional reaching tasks.Experimental brain research · 2019Article
- A Unifying Pathophysiological Account for Post-stroke Spasticity and Disordered Motor Control.Frontiers in neurology · 2019Article
- StartReact during gait initiation reveals differential control of muscle activation and inhibition in patients with corticospinal degeneration.Journal of neurology · 2018Article
- A startling acoustic stimulus facilitates voluntary lower extremity movements and automatic postural responses in people with chronic stroke.Journal of neurology · 2018Article
- StartReact effects in first dorsal interosseous muscle are absent in a pinch task, but present when combined with elbow flexion.PloS one · 2018Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveA startling loud acoustic stimulus can involuntarily elicit planned movements, a phenomenon referred to as startReact. Following stroke, startReact elbow flexion in stroke survivors are improved from voluntary movements. Specifically, startReact elbow flexion in unimpaired individuals is not statistically different from stroke survivors in terms of onset latency and muscle activation patterns. As hand movements are particularly impacted by stroke, our objective was to determine if startReact was intact in the hand following stroke.
methodsData were collected in 8 stroke survivors and 10 age-matched subjects performing hand extension following two non-startling acoustic stimuli representing "get ready" and "go" respectively. Randomly, the "go" was replaced with a startling acoustic stimulus. We hypothesized that (1) startReact would be intact during hand extension in stroke survivors and that (2) the latency of movement would be the same as in age-matched subjects.
resultsWe found that startReact was intact in stroke subjects and further that the onset latency of these movements was not different from age-matched subjects.
conclusionsWe conclude that startReact is intact in the hand following stroke. SIGNIFICANCE: An intact startReact response indicates that this reflex may be an attractive therapeutic target for initiating hand extension in stroke survivors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.