Evidence map›Paper›PMID 25002294›Full record

ArticleThe American journal of tropical medicine and hygiene2014

Elevation of soluble intercellular adhesion molecule-1 levels, but not angiopoietin 2, in the plasma of human immunodeficiency virus-infected African women with clinical Kaposi sarcoma.

Susan M Graham, Nimerta Rajwans, Barbra A Richardson, Walter Jaoko, R Scott McClelland, Julie Overbaugh, W Conrad Liles

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Susan M GrahamDepartments of Medicine, Global Health, and Epidemiology, and Department of Biostatistics, University of Washington, Seattle, Washington; Institute of Tropical and Infectious Diseases, and Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya; Office of Research Trainees, Toronto General Hospital-University Health Network, and Division of Infectious Diseases, Department of Medicine University of Toronto, Toronto, Ontario, Canada; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington grahamsm@uw.edu.
Nimerta RajwansDepartments of Medicine, Global Health, and Epidemiology, and Department of Biostatistics, University of Washington, Seattle, Washington; Institute of Tropical and Infectious Diseases, and Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya; Office of Research Trainees, Toronto General Hospital-University Health Network, and Division of Infectious Diseases, Department of Medicine University of Toronto, Toronto, Ontario, Canada; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Barbra A RichardsonDepartments of Medicine, Global Health, and Epidemiology, and Department of Biostatistics, University of Washington, Seattle, Washington; Institute of Tropical and Infectious Diseases, and Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya; Office of Research Trainees, Toronto General Hospital-University Health Network, and Division of Infectious Diseases, Department of Medicine University of Toronto, Toronto, Ontario, Canada; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Walter JaokoDepartments of Medicine, Global Health, and Epidemiology, and Department of Biostatistics, University of Washington, Seattle, Washington; Institute of Tropical and Infectious Diseases, and Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya; Office of Research Trainees, Toronto General Hospital-University Health Network, and Division of Infectious Diseases, Department of Medicine University of Toronto, Toronto, Ontario, Canada; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington.
R Scott McClellandDepartments of Medicine, Global Health, and Epidemiology, and Department of Biostatistics, University of Washington, Seattle, Washington; Institute of Tropical and Infectious Diseases, and Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya; Office of Research Trainees, Toronto General Hospital-University Health Network, and Division of Infectious Diseases, Department of Medicine University of Toronto, Toronto, Ontario, Canada; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Julie OverbaughDepartments of Medicine, Global Health, and Epidemiology, and Department of Biostatistics, University of Washington, Seattle, Washington; Institute of Tropical and Infectious Diseases, and Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya; Office of Research Trainees, Toronto General Hospital-University Health Network, and Division of Infectious Diseases, Department of Medicine University of Toronto, Toronto, Ontario, Canada; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington.
W Conrad LilesDepartments of Medicine, Global Health, and Epidemiology, and Department of Biostatistics, University of Washington, Seattle, Washington; Institute of Tropical and Infectious Diseases, and Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya; Office of Research Trainees, Toronto General Hospital-University Health Network, and Division of Infectious Diseases, Department of Medicine University of Toronto, Toronto, Ontario, Canada; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington.
University Health Network · CA

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Kenneth Sherr · 1988 to 2026
$104.9M
EARLY INFECTION IN WOMEN EXPOSED MUCOSALLY TO HIV-1R37AI038518 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI OVERBAUGH, JULIE M. · 1999 to 2019
$12.9M
Antiretroviral Therapy and HIV-1 Infectivity in WomenR01AI058698 · NIAID · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, RAYMOND SCOTT · 2005 to 2010
$2.8M
Antiretroviral Therapy and HIV-1 Infectivity in WomenR56AI058698 · NIAID · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, RAYMOND SCOTT · 2011 to 2011
$390k
EARLY INFECTION IN WOMEN EXPOSED MUCOSALLY TO HIV-1R01AI038518 · NIAID · UNIVERSITY OF WASHINGTON · PI OVERBAUGH, JULIE M · 1995 to 1998
–
CIHRNIAID NIH HHS AI-38518NIAID NIH HHS AI-58698NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI058698NIAID NIH HHS R37 AI038518NIAID NIH HHS R56 AI058698
6 · The paper itself

Abstract

Circulating levels of endothelial activation biomarkers are elevated in during infection with human immunodeficiency virus 1 (HIV-1) and may also be increased in Kaposi sarcoma (KS). We compared 23 HIV-1-seropositive women with clinically diagnosed KS with 46 randomly selected controls matched for visit year, CD4 count, and antiretroviral therapy status. Conditional logistic regression was used to identify differences between cases and controls. The odds of clinical KS increased with increasing plasma viral load and with intercellular adhesion molecule 1 (ICAM-1) levels above or equal to the median. There was a borderline association between increasing plasma angiopoietin 2 levels and KS. In multivariable modeling including plasma viral load, angiopoietin 2, and ICAM-1, plasma ICAM-1 levels above or equal to the median remained associated with clinical KS (odds ratio = 14.2, 95% confidence interval = 2.3-87.7). Circulating ICAM-1 levels should be evaluated as a potential biomarker for disease progression and treatment response among HIV-infected KS patients.

Indexed as

AdultAfricaAngiopoietin-2BiomarkersCase-Control StudiesCD4 Lymphocyte CountDisease ProgressionDNA, ViralFemaleHIV-1HIV InfectionsHumansIntercellular Adhesion Molecule-1Logistic ModelsOdds RatioSarcoma, KaposiAngiopoietin-2ANGPT2 protein, humanBiomarkersDNA, ViralIntercellular Adhesion Molecule-1

Identifiers

PMID25002294
PMCPMC4183391
OpenAlexW2328207242

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.