ArticleNeuron2014
Control of interneuron firing by subthreshold synaptic potentials in principal cells of the dorsal cochlear nucleus.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Cochlear nucleus spatial transcriptomes of normal and hearing loss mice reveal a critical role of Spp1 in bushy cells.Cell research · 2026Article
- Photomapping electrically coupled networks of the mature thalamus and cortex.bioRxiv : the preprint server for biology · 2026Article
- Calcium-Sensitive Subthreshold Oscillations and Electrical Coupling in Principal Cells of Mouse Dorsal Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The NaeLife · 2024Article
- The NabioRxiv : the preprint server for biology · 2023Article
- D-type K+ current rules the function of electrically coupled neurons in a species-specific fashion.The Journal of general physiology · 2023Article
- Connexin36 RNA Expression in the Cochlear Nucleus of the Echolocating Bat, Eptesicus fuscus.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Article
- Function and Plasticity of Electrical Synapses in the Mammalian Brain: Role of Non-Junctional Mechanisms.Biology · 2022Review
- On the Diverse Functions of Electrical Synapses.Frontiers in cellular neuroscience · 2022Review
- Beyond plasticity: the dynamic impact of electrical synapses on neural circuits.Nature reviews. Neuroscience · 2019Review
- Serotonergic Modulation of Sensory Representation in a Central Multisensory Circuit Is Pathway Specific.Cell reports · 2017Article
- A calcium-dependent pathway underlies activity-dependent plasticity of electrical synapses in the thalamic reticular nucleus.The Journal of physiology · 2017Article
- Synchrony and so much more: Diverse roles for electrical synapses in neural circuits.Developmental neurobiology · 2017Review
- Early multisensory integration of self and source motion in the auditory system.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Functional organization of the mammalian auditory midbrain.The journal of physiological sciences : JPS · 2015Review
- Article
- Serotonergic regulation of excitability of principal cells of the dorsal cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Superficial stellate cells of the dorsal cochlear nucleus.Frontiers in neural circuits · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Voltage-gated ion channels amplify, compartmentalize, and normalize synaptic signals received by neurons. We show that voltage-gated channels activated during subthreshold glutamatergic synaptic potentials in a principal cell generate an excitatory→inhibitory synaptic sequence that excites electrically coupled interneurons. In fusiform cells of the dorsal cochlear nucleus, excitatory synapses activate a TTX-sensitive Na(+) conductance and deactivate a resting Ih conductance, leading to a striking reshaping of the synaptic potential. Subthreshold voltage changes resulting from activation/deactivation of these channels subsequently propagate through gap junctions, causing slow excitation followed by inhibition in GABAergic stellate interneurons. Gap-junction-mediated transmission of voltage-gated signals accounts for the majority of glutamatergic signaling to interneurons, such that subthreshold synaptic events from a single principal cell are sufficient to drive spikes in coupled interneurons. Thus, the interaction between a principal cell's synaptic and voltage-gated channels may determine the spike activity of networks without firing a single action potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.