ReviewNature reviews. Urology2014
Voiding dysfunction due to detrusor underactivity: an overview.
Review in Nature reviews. Urology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- De Novo Detrusor Underactivity and Other Urodynamic Findings after Radical Prostatectomy: A Systematic Review.Medicina (Kaunas, Lithuania) · 2022Pooled it
- A cross-shaped combined ultrasound array patch for continuous bladder volume monitoring.Photoacoustics · 2026Article
- Therapeutic efficacy and predictive factors for treatment outcomes of transurethral incision of the bladder neck in women with voiding dysfunction due to an underactive bladder.International urology and nephrology · 2026Article
- Article
- BOOI-Defined Obstruction Stratifies Early Outcomes After ThuLEP in Men With Detrusor Underactivity: A Retrospective Complete-Case Cohort Study.Lower urinary tract symptoms · 2026Article
- Detrusor Underactivity and Acontractile Bladder Patients Performing Clean Intermittent Catheterization in a Single Tertiary Referral Center: What is Happening in Real Life?International urogynecology journal · 2025Article
- Efficacy of Holmium Laser Enucleation of the Prostate in Patients With Detrusor Underactivity or Acontractile Bladder.International neurourology journal · 2025Article
- Four Years' Experience at a Single Referral Center Regarding Urodynamic Findings in Women With Voiding Dysfunction.Journal of family & reproductive health · 2025Article
- Article
- Prevalence and predictors of detrusor underactivity and bladder outlet obstruction in women with lower urinary tract symptoms.Scientific reports · 2024Article
- A wireless, battery-free device for electrical neuromodulation of bladder contractions.Materials today. Bio · 2024Article
- Increased age and the volume of intraoperative fluid administered predict urinary retention after elective inguinal herniorrhaphy.Perioperative medicine (London, England) · 2024Article
- Transcriptomics Reveals Molecular Features of the Bilateral Pelvic Nerve Injury Rat Model of Detrusor Underactivity.Biomolecules · 2023Article
- Bladder Replacement Therapy.Bladder (San Francisco, Calif.) · 2023Review
- Impact of sacrocolpopexy for the management of pelvic organ prolapse on voiding dysfunction and uroflowmetry parameters: a prospective cohort study.Archives of gynecology and obstetrics · 2022Article
- Magnetic soft robotic bladder for assisted urination.Science advances · 2022Article
- 3D Bioprinting of an In Vitro Model of a Biomimetic Urinary Bladder with a Contract-Release System.Micromachines · 2022Article
- Astragaloside IV Protects Detrusor from Partial Bladder Outlet Obstruction-Induced Oxidative Stress by Activating Mitophagy through AMPK-ULK1 Pathway.Oxidative medicine and cellular longevity · 2022Article
- A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats.Scientific reports · 2021Article
- Expandable and implantable bioelectronic complex for analyzing and regulating real-time activity of the urinary bladder.Science advances · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detrusor underactivity (DUA) is defined as a voiding contraction of reduced strength and/or duration, which prolongs urination and/or prevents complete emptying of the bladder within a 'normal' period of time. This issue is associated with voiding and postmicturition urinary symptoms, and can predispose to urinary infections and acute urinary retention. The aetiology of DUA is influenced by multiple factors, including ageing, bladder outlet obstruction, neurological disease, and autonomic denervation. The true prevalence of this condition remains unknown, as most data come from referral populations. Urodynamic testing is used to diagnose the condition, either by assessing the relationship between bladder pressures and urinary flow, or by interrupting voiding to measure detrusor pressure change under isovolumetric conditions. Current treatments for DUA have poor efficacy and tolerability, and often fail to improve quality of life; muscarinic receptor agonists, in particular, have limited efficacy and frequent adverse effects. Bladder emptying might be achieved through Valsalva straining, and intermittent or indwelling catheterization, although sacral nerve stimulation can reduce dependency on catheterization. Novel stem-cell-based therapies have been attempted; however, new drugs that increase contractility are currently largely conceptual, and the complex pathophysiology of DUA, difficulty achieving organ specificity of treatment, the limited availability of animal models, and the subjective nature of current outcome measures must be addressed to facilitate the development of such agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.