ReviewAnnual review of microbiology2014
Subterfuge and sabotage: evasion of host innate defenses by invasive gram-positive bacterial pathogens.
Review in Annual review of microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 78 citations in OpenAlex.
- AliC and AliD of nonencapsulatedFrontiers in cellular and infection microbiology · 2025Article
- Mechanisms of host adaptation by bacterial pathogens.FEMS microbiology reviews · 2024Review
- Increasing Rate of FatalMicroorganisms · 2024Article
- Interplay between group AMicrobiology and molecular biology reviews : MMBR · 2024Review
- Targeting host deoxycytidine kinase mitigateseLife · 2024Article
- Immunomodulating Enzymes fromMicroorganisms · 2024Review
- Inactivation of the Sts enzymes promotes resistance to lethalInfection and immunity · 2023Article
- Heterogeneity of the group B streptococcal type VII secretion system and influence on colonization of the female genital tract.Molecular microbiology · 2023Article
- Host inflammatory dynamics reveal placental immune modulation by Group B Streptococcus during pregnancy.Molecular systems biology · 2023Article
- A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function.EMBO molecular medicine · 2023Article
- Heterogeneity of the group B streptococcal type VII secretion system and influence on colonization of the female genital tract.bioRxiv : the preprint server for biology · 2023Article
- Methods to Analyze the Contribution of Complement Evasion Factor (CEF) to Streptococcus pyogenes Virulence.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Heme-Dependent Siderophore Utilization Promotes Iron-Restricted Growth of the Staphylococcus aureusJournal of bacteriology · 2021Article
- Contribution of Coagulase and Its Regulator SaeRS to Lethality of CA-MRSA 923 Bacteremia.Pathogens (Basel, Switzerland) · 2021Article
- NAD+ pool depletion as a signal for the Rex regulon involved in Streptococcus agalactiae virulence.PLoS pathogens · 2021Article
- Article
- The cysteine protease ApdS fromThe Journal of biological chemistry · 2019Article
- Group AMicrobiology spectrum · 2019Article
- MntC-Dependent Manganese Transport Is Essential formSphere · 2018Article
- Innate Immunity toJournal of immunology (Baltimore, Md. : 1950) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The development of a severe invasive bacterial infection in an otherwise healthy individual is one of the most striking and fascinating aspects of human medicine. A small cadre of gram-positive pathogens of the genera Streptococcus and Staphylococcus stand out for their unique invasive disease potential and sophisticated ability to counteract the multifaceted components of human innate defense. This review illustrates how these leading human disease agents evade host complement deposition and activation, impede phagocyte recruitment and activation, resist the microbicidal activities of host antimicrobial peptides and reactive oxygen species, escape neutrophil extracellular traps, and promote and accelerate phagocyte cell death through the action of pore-forming cytolysins. Understanding the molecular basis of bacterial innate immune resistance can open new avenues for therapeutic intervention geared to disabling specific virulence factors and resensitizing the pathogen to host innate immune clearance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.