Evidence map›Paper›PMID 25001617›Full record

ReviewNeuroscience bulletin2014

Regulatory mechanisms underlying the differential growth of dendrites and axons.

Xin Wang, Gabriella R Sterne, Bing Ye

Abstract readReview
In one paragraph

Review in Neuroscience bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. DIP2B Interacts With α-Tubulin to Regulate Axon Outgrowth.Frontiers in cellular neuroscience · 2020
    Article
  4. Article
  5. Article
  6. Frontiers in cellular neuroscience · 2019
    Article
  7. Review
  8. Article
  9. Transcriptional Reorganization ofFrontiers in molecular neuroscience · 2017
    Article
  10. Neurodevelopment and degeneration.Neuroscience bulletin · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xin WangLife Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA.
Gabriella R Sterne
Bing Ye

Funding

Signaling Pathways That Differentiate Dendrite and Axon DevelopmentR01MH091186 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YE, BING · 2010 to 2014
$1.9M
The role of the secretory pathway in ethanol-induced neural tissue injuryR21AA021204 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YE, BING · 2013 to 2014
$403k
NIAAA NIH HHS R21AA021204NIMH NIH HHS R01MH091186
6 · The paper itself

Abstract

A typical neuron is comprised of an information input compartment, or the dendrites, and an output compartment, known as the axon. These two compartments are the structural basis for functional neural circuits. However, little is known about how dendritic and axonal growth are differentially regulated. Recent studies have uncovered two distinct types of regulatory mechanisms that differentiate dendritic and axonal growth: dedicated mechanisms and bimodal mechanisms. Dedicated mechanisms regulate either dendritespecific or axon-specific growth; in contrast, bimodal mechanisms direct dendritic and axonal development in opposite manners. Here, we review the dedicated and bimodal regulators identified by recent Drosophila and mammalian studies. The knowledge of these underlying molecular mechanisms not only expands our understanding about how neural circuits are wired, but also provides insights that will aid in the rational design of therapies for neurological diseases.

Indexed as

AnimalsAxonsDendritesDrosophilaDrosophila ProteinsHumansIntercellular Signaling Peptides and ProteinsTranscription FactorsDrosophila ProteinsIntercellular Signaling Peptides and ProteinsTranscription Factors

Identifiers

PMID25001617
PMCPMC5562626

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.