ArticleInfection and immunity2014
Brucella melitensis invades murine erythrocytes during infection.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Role of channels in the ObioRxiv : the preprint server for biology · 2025Article
- Unraveling brucellosis: advances in pathogenesis, diagnostic strategies, therapeutic innovations, and public health perspectives.Frontiers in medicine · 2025Review
- Genome-wide analysis of Brucella melitensis growth in spleen of infected mice allows rational selection of new vaccine candidates.PLoS pathogens · 2024Article
- Contrasting roles for IgM and B-cell MHCII expression inmSphere · 2024Article
- Cell and Tissue Tropism of Brucella spp.Infection and immunity · 2023Review
- Kinetics of Placental Infection by Different SmoothPathogens (Basel, Switzerland) · 2022Article
- Cross-sectional study of Brucella spp. using real-time PCR from bovine whole blood in Colombia.Veterinary research communications · 2022Article
- Review
- Review
- Adhesins ofPathogens (Basel, Switzerland) · 2020Review
- The Healthy Human Blood Microbiome: Fact or Fiction?Frontiers in cellular and infection microbiology · 2019Review
- Route of Infection Strongly Impacts the Host-Pathogen Relationship.Frontiers in immunology · 2019Article
- Pathological changes and bacteriological assessments in the urinary tract of pregnant goats experimentally infected with Brucella melitensis.BMC veterinary research · 2018Article
- Tissue distribution and cell tropism of Brucella canis in naturally infected canine foetuses and neonates.Scientific reports · 2018Article
- Comparative Ecology ofFrontiers in veterinary science · 2018Review
- Persistence ofJournal of immunology research · 2018Article
- Article
- Relative Quantitative Proteomic Analysis ofFrontiers in microbiology · 2017Article
- Article
- Imaging flow cytometry analysis of intracellular pathogens.Methods (San Diego, Calif.) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brucella spp. are facultative intracellular Gram-negative coccobacilli responsible for brucellosis, a worldwide zoonosis. We observed that Brucella melitensis is able to persist for several weeks in the blood of intraperitoneally infected mice and that transferred blood at any time point tested is able to induce infection in naive recipient mice. Bacterial persistence in the blood is dramatically impaired by specific antibodies induced following Brucella vaccination. In contrast to Bartonella, the type IV secretion system and flagellar expression are not critically required for the persistence of Brucella in blood. ImageStream analysis of blood cells showed that following a brief extracellular phase, Brucella is associated mainly with the erythrocytes. Examination by confocal microscopy and transmission electron microscopy formally demonstrated that B. melitensis is able to invade erythrocytes in vivo. The bacteria do not seem to multiply in erythrocytes and are found free in the cytoplasm. Our results open up new areas for investigation and should serve in the development of novel strategies for the treatment or prophylaxis of brucellosis. Invasion of erythrocytes could potentially protect the bacterial cells from the host's immune response and hamper antibiotic treatment and suggests possible Brucella transmission by bloodsucking insects in nature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.