Trial reportBrain : a journal of neurology2014
Motor co-activation in siblings of patients with juvenile myoclonic epilepsy: an imaging endophenotype?
Trial report in Brain : a journal of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Gray Matter Changes in Juvenile Myoclonic Epilepsy. A Voxel-Wise Meta-Analysis.Medicina (Kaunas, Lithuania) · 2021Pooled it
- Magnetoencephalography Reveals a Widespread Increase in Network Connectivity in Idiopathic/Genetic Generalized Epilepsy.PloS one · 2015Trial
- Article
- Endophenotype Research in Epilepsy Across Time.Brain sciences · 2025Article
- Brain activation and connection across resting and motor-task states in patients with generalized tonic-clonic seizures.CNS neuroscience & therapeutics · 2024Article
- Identification of different MRI atrophy progression trajectories in epilepsy by subtype and stage inference.Brain : a journal of neurology · 2023Article
- The Impact of Sociodemographic Disadvantage on Cognitive Outcomes in Children With Newly Diagnosed Seizures and Their Unaffected Siblings Over 36 Months.Pediatric neurology · 2023Article
- Article
- Multimodal connectome biomarkers of cognitive and affective dysfunction in the common epilepsies.Network neuroscience (Cambridge, Mass.) · 2022Article
- Genetic generalized epilepsies in adults - challenging assumptions and dogmas.Nature reviews. Neurology · 2022Review
- Neuroimaging in the Epileptic Baboon.Frontiers in veterinary science · 2022Review
- Neurobehavioural comorbidities of epilepsy: towards a network-based precision taxonomy.Nature reviews. Neurology · 2021Review
- Heritability of Magnetoencephalography Phenotypes Among Patients With Genetic Generalized Epilepsy and Their Siblings.Neurology · 2021Article
- Common Brain Substrates Underlying Auditory Speech Priming and Perceived Spatial Separation.Frontiers in neuroscience · 2021Article
- Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study.Science advances · 2020Article
- Juvenile myoclonic epilepsy shows increased posterior theta, and reduced sensorimotor beta resting connectivity.Epilepsy research · 2020Article
- Motor hyperactivation during cognitive tasks: An endophenotype of juvenile myoclonic epilepsy.Epilepsia · 2020Article
- Neural correlates of verbal working memory in children with epilepsy with centro-temporal spikes.NeuroImage. Clinical · 2020Article
- Cognitive Function in Genetic Generalized Epilepsies: Insights From Neuropsychology and Neuroimaging.Frontiers in neurology · 2020Review
- Impaired Cognitive Abilities in Siblings of Patients with Temporal Lobe Epilepsy.Neuropsychiatric disease and treatment · 2020Article
Corrections and comments
- Commented on by
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Juvenile myoclonic epilepsy is a heritable idiopathic generalized epilepsy syndrome, characterized by myoclonic jerks and frequently triggered by cognitive effort. Impairment of frontal lobe cognitive functions has been reported in patients with juvenile myoclonic epilepsy and their unaffected siblings. In a recent functional magnetic resonance imaging study we reported abnormal co-activation of the motor cortex and increased functional connectivity between the motor system and prefrontal cognitive networks during a working memory paradigm, providing an underlying mechanism for cognitively triggered jerks. In this study, we used the same task in 15 unaffected siblings (10 female; age range 18-65 years, median 40) of 11 of those patients with juvenile myoclonic epilepsy (six female; age range 22-54 years, median 35) and compared functional magnetic resonance imaging activations with 20 age- and gender-matched healthy control subjects (12 female; age range 23-46 years, median 30.5). Unaffected siblings showed abnormal primary motor cortex and supplementary motor area co-activation with increasing cognitive load, as well as increased task-related functional connectivity between motor and prefrontal cognitive networks, with a similar pattern to patients (P < 0.001 uncorrected; 20-voxel threshold extent). This finding in unaffected siblings suggests that altered motor system activation and functional connectivity is not medication- or seizure-related, but represents a potential underlying mechanism for impairment of frontal lobe functions in both patients and siblings, and so constitutes an endophenotype of juvenile myoclonic epilepsy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.