Evidence map›Paper›PMID 25001461›Full record

ArticleThe Journal of infectious diseases2015

Interleukin 17 expression in peripheral blood neutrophils from fungal keratitis patients and healthy cohorts in southern India.

Rajapandian Sivaganesa Karthikeyan, Chairut Vareechon, Namperumalsamy Venkatesh Prajna, Kuppamuthu Dharmalingam, Eric Pearlman, Prajna Lalitha

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Endogenous stimulation is responsible for the high frequency of IL-17A-producing neutrophils in patients with rheumatoid arthritis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2019
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review of clinical and basic approaches of fungal keratitis.International journal of ophthalmology · 2016
    Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Rajapandian Sivaganesa KarthikeyanDr G. Venkatasamy Eye Research Institute, Aravind Eye Hospital, Tamil Nadu, India.
Chairut VareechonDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio.
Namperumalsamy Venkatesh PrajnaDr G. Venkatasamy Eye Research Institute, Aravind Eye Hospital, Tamil Nadu, India.
Kuppamuthu DharmalingamDr G. Venkatasamy Eye Research Institute, Aravind Eye Hospital, Tamil Nadu, India.
Eric PearlmanDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio.
Prajna LalithaDr G. Venkatasamy Eye Research Institute, Aravind Eye Hospital, Tamil Nadu, India.
Aravind Eye Hospital · INCase Western Reserve University · US

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
Pathogenesis of Fungal KeratitisR01EY018612 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PEARLMAN, ERIC · 2008 to 2022
$6.9M
NEI NIH HHS P30 EY011373NEI NIH HHS R01 EY018612
6 · The paper itself

Abstract

Interleukin 17A (IL-17) production by peripheral blood neutrophils was examined in patients with fungal keratitis and in uninfected individuals in southern India, which has high levels of airborne Aspergillus and Fusarium conidia. Il17a gene expression and intracellular IL-17 were detected in all groups, although levels were significantly elevated in neutrophils from patients with keratitis. There were no significant differences in plasma IL-17 and IL-23 between patients with keratitis and uninfected individuals; however, combined data from all groups showed a correlation between the percentage IL-17 producing neutrophils and plasma IL-23, and between plasma IL-17 and IL-6 and IL-23.

Indexed as

AdultAspergillosisAspergillusCase-Control StudiesCohort StudiesEye Infections, FungalFusariosisFusariumHumansIndiaInterleukin-17Interleukin-23Interleukin-6KeratitisMiddle AgedNeutrophilsInterleukin-17Interleukin-23Interleukin-6Aspergilluscorneal ulcerfungal infectionFusariumIL-17IL-23keratitisneutrophil

Identifiers

PMID25001461
PMCPMC4402381
OpenAlexW2122219540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.