ArticleJournal of the American Society for Mass Spectrometry2014
Ion-molecule clustering in differential mobility spectrometry: lessons learned from tetraalkylammonium cations and their isomers.
Article in Journal of the American Society for Mass Spectrometry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The trial behind it
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Who cites it
16 citing papers in PubMed.
- Comparison of ESI and APPI for the Detection of Nitro Explosives Using Differential Mobility Mass Spectrometry.ACS omega · 2026Article
- Determining the gas-phase structures of α-helical peptides from shape, microsolvation, and intramolecular distance data.Nature communications · 2023Article
- Separating chiral isomers of amphetamine and methamphetamine using chemical derivatization and differential mobility spectrometry.Analytical science advances · 2020Article
- A First Principle Model of Differential Ion Mobility: the Effect of Ion-Solvent Clustering.Journal of the American Society for Mass Spectrometry · 2019Article
- Preferential Ion Microsolvation in Mixed-Modifier Environments Observed Using Differential Mobility Spectrometry.Journal of the American Society for Mass Spectrometry · 2019Article
- Separation of Sialylated Glycan Isomers by Differential Mobility Spectrometry.Analytical chemistry · 2019Article
- Recommendations for reporting ion mobility Mass Spectrometry measurements.Mass spectrometry reviews · 2019Review
- Determining molecular properties with differential mobility spectrometry and machine learning.Nature communications · 2018Article
- Differential mobility spectrometry (DMS) reveals the elevation of urinary acetylcarnitine in non-human primates (NHPs) exposed to radiation.Journal of mass spectrometry : JMS · 2018Article
- Resolution and Assignment of Differential Ion Mobility Spectra of Sarcosine and Isomers.Journal of the American Society for Mass Spectrometry · 2018Article
- Analyzing Glycopeptide Isomers by Combining Differential Mobility Spectrometry with Electron- and Collision-Based Tandem Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2017Article
- Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry.ACS central science · 2017Article
- Studying Gas-Phase Interconversion of Tautomers Using Differential Mobility Spectrometry.Journal of the American Society for Mass Spectrometry · 2016Article
- Differential mobility spectrometry: a valuable technology for analyzing challenging biological samples.Bioanalysis · 2015Article
- Three-dimensional enhanced lipidomics analysis combining UPLC, differential ion mobility spectrometry, and mass spectrometric separation strategies.Journal of lipid research · 2014Article
- Characterization of acyl chain position in unsaturated phosphatidylcholines using differential mobility-mass spectrometry.Journal of lipid research · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differential mobility spectrometry (DMS) can distinguish ions based upon the differences in their high- and low-field ion mobilities as they experience the asymmetric waveform applied to the DMS cell. These mobilities are known to be influenced by the ions' structure, m/z, and charge distribution (i.e., resonance structures) within the ions themselves, as well as by the gas-phase environment of the DMS cell. While these associations have been developed over time through empirical observations, the exact role of ion structures or their interactions with clustering molecules remains generally unknown. In this study, that relationship is explored by observing the DMS behaviors of a series of tetraalkylammonium ions as a function of their structures and the gas-phase environment of the DMS cell. To support the DMS experiments, the basin-hopping search strategy was employed to identify candidate cluster structures for density functional theory treatment. More than a million cluster structures distributed across 72 different ion-molecule cluster systems were sampled to determine global minimum structures and cluster binding energies. This joint computational and experimental approach suggests that cluster geometry, in particular ion-molecule intermolecular separation, plays a critical role in DMS.
Identifiers
25001379What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.