ArticleAntimicrobial agents and chemotherapy2014
Cysticidal activity of antifungals against different genotypes of Acanthamoeba.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Promising Drug Repurposing Candidates Targeting Free-Living Amoebae: A Systematic and Critical Review of Laboratory-Based Evidence.Pathogens (Basel, Switzerland) · 2026Pooled it
- Pooled it
- Silver(I)-NHC Complexes as Dual-Action Agents Against PathogenicInternational journal of molecular sciences · 2025Article
- Effect of Cinnamaldehyde and Its Nanoemulsion on Acanthamoeba castellanii Cysts and Trophozoites.Acta parasitologica · 2025Article
- Review
- Understanding Acanthamoeba Keratitis: An In-Depth Review of a Sight-Threatening Eye Infection.Microorganisms · 2024Review
- Development of a Machine Learning-Based Cysticidal Assay and Identification of an Amebicidal and Cysticidal Marine Microbial Metabolite againstMicrobiology spectrum · 2022Article
- Overnight orthokeratology-associated Acanthamoeba keratitis at a tertiary referral hospital in Taiwan: A retrospective case-control study.Journal of the Chinese Medical Association : JCMA · 2022Article
- Evaluation of Amebicidal and Cysticidal Activities of Antifungal Drug Isavuconazonium Sulfate againstPharmaceuticals (Basel, Switzerland) · 2021Article
- [Coinfections in contact lens-associated mycotic keratitis with Pseudomonas or Acanthamoeba].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021Article
- Challenges in Acanthamoeba Keratitis: A Review.Journal of clinical medicine · 2021Review
- The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii.Antimicrobial agents and chemotherapy · 2020Article
- Outcomes of a Dispersive Ophthalmic Viscosurgical Device.Beyoglu eye journal · 2020Article
- Acanthamoeba Keratitis Associated with Scleral Contact Lens Use in a Keratoconus Patient.Beyoglu eye journal · 2020Article
- Acanthamoeba genotypes T3 and T4 as causative agents of amoebic keratitis in Mexico.Parasitology research · 2016Article
- Fluorinated Sterols Are Suicide Inhibitors of Ergosterol Biosynthesis and Growth in Trypanosoma brucei.Chemistry & biology · 2015Article
- Dendrite-like anterior stromal keratitis coinfected withTaiwan journal of ophthalmologyArticle
- Rapid resolution of stromal keratitis with the assistance of oral voriconazole in resistant acanthamoeba keratitis.Taiwan journal of ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antifungal drugs have been proposed as a novel treatment for Acanthamoeba keratitis. The cysticidal activity of several antifungal compounds was tested against different genotypes of culture collection and clinical isolates of Acanthamoeba. Only voriconazole and posaconazole were found to be cysticidal, with no differences in activity observed between clinical and culture collection isolates.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.