ArticleCell reports2014
PAS kinase drives lipogenesis through SREBP-1 maturation.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- HN1-mediated activation of lipogenesis through Akt-SREBP signaling promotes hepatocellular carcinoma cell proliferation and metastasis.Cancer gene therapy · 2024Article
- SIKs Regulate HDAC7 Stabilization and Cytokine Recall in Late-Stage T Cell Effector Differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Metabolic "Sense Relay" in Stem Cells: A Short But Impactful Life of PAS Kinase Balancing Stem Cell Fates.Cells · 2023Review
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- Preventing Oxidative Stress in the Liver: An Opportunity for GLP-1 and/or PASK.Antioxidants (Basel, Switzerland) · 2021Review
- Discovery of a potent FKBP38 agonist that ameliorates HFD-induced hyperlipidemiaActa pharmaceutica Sinica. B · 2021Article
- Decidualized endometrial stromal cells present with altered androgen response in PCOS.Scientific reports · 2021Article
- Storage and Utilization of Glycogen by Mouse Liver during Adaptation to Nutritional Changes Are GLP-1 and PASK Dependent.Nutrients · 2021Article
- Gut Microbiota Regulates the Interaction between Diet and Genetics to Influence Glucose Tolerance.Medicines (Basel, Switzerland) · 2021Article
- Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum.Cell chemical biology · 2021Article
- ALS-associated genes in SCA2 mouse spinal cord transcriptomes.Human molecular genetics · 2020Article
- Validation of PAS Kinase, a Regulator of Hepatic Fatty Acid and Triglyceride Synthesis, as a Therapeutic Target for Nonalcoholic Steatohepatitis.Hepatology communications · 2020Article
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- Recent Insights Into SREBP as a Direct Mediator of Kidney Fibrosis via Lipid-Independent Pathways.Frontiers in pharmacology · 2020Review
- PAS Kinase: A Nutrient and Energy Sensor "Master Key" in the Response to Fasting/Feeding Conditions.Frontiers in endocrinology · 2020Review
- The metabolic sensor PASK is a histone 3 kinase that also regulates H3K4 methylation by associating with H3K4 MLL2 methyltransferase complex.Nucleic acids research · 2019Article
- Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Regulation of Cbf1 by PAS Kinase Is a Pivotal Control Point for LipogenesisG3 (Bethesda, Md.) · 2019Article
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Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Elevated hepatic synthesis of fatty acids and triglycerides, driven by hyperactivation of the SREBP-1c transcription factor, has been implicated as a causal feature of metabolic syndrome. SREBP-1c activation requires the proteolytic maturation of the endoplasmic-reticulum-bound precursor to the active, nuclear transcription factor, which is stimulated by feeding and insulin signaling. Here, we show that feeding and insulin stimulate the hepatic expression of PASK. We also demonstrate, using genetic and pharmacological approaches, that PASK is required for the proteolytic maturation of SREBP-1c in cultured cells and in the mouse and rat liver. Inhibition of PASK improves lipid and glucose metabolism in dietary animal models of obesity and dyslipidemia. Administration of a PASK inhibitor decreases hepatic expression of lipogenic SREBP-1c target genes, decreases serum triglycerides, and partially reverses insulin resistance. While the signaling network that controls SREBP-1c activation is complex, we propose that PASK is an important component with therapeutic potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.