ArticleAnnals of surgical oncology2014
Failure of radioactive iodine in the treatment of hyperthyroidism.
Article in Annals of surgical oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Predictive factors of radioactive iodine therapy failure in hyperthyroidism: a retrospective study of 171 patients.The Pan African medical journal · 2025Article
- Prospective study to evaluate radioactive iodine of 20 mCi vs 10-15 mCi in Graves' disease.BMC endocrine disorders · 2024Article
- Ultrasound combined with Ki-67 to construct the prognostic model for radioactive iodine therapy outcomes in Graves' disease patients.Endocrine connections · 2024Article
- Preconceptional Counseling in Women with Hyperthyroidism.Medicina (Kaunas, Lithuania) · 2024Review
- Advancing Preoperative Strategies for Thyroidectomy in Graves' Disease: A Narrative Review.Cureus · 2023Review
- Time to Symptom Resolution After Total Thyroidectomy for Graves' Disease.The Journal of surgical research · 2023Article
- [Ultrasound combined with Ki67 detection for analyzing contributing factors of failure to cure and recurrence of hyperthyroidism in patients with Graves disease afterNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Efficacy of Radioiodine Therapy in Patients With Primary Hyperthyroidism: An Institutional Review From Pakistan.Cureus · 2022Article
- Predicting outcomes in hyperthyroid cats treated with radioiodine.Journal of veterinary internal medicine · 2022Article
- First Case Report of Arrhythmogenic Right Ventricular Cardiomyopathy Showing Refractory Ventricular Tachycardia Induced by Thyroid Storm due to Graves' Disease.Case reports in endocrinology · 2022Article
- Total versus near-total thyroidectomy in Graves' disease: a systematic review and meta-analysis of comparative studies.Gland surgery · 2021Article
- Predictors of euthyreosis in hyperthyroid patients treated with radioiodineBMC endocrine disorders · 2020Article
- Hyperthyroidism.Gland surgery · 2020Review
- Radioiodine therapy and Graves' disease - Myths and reality.PloS one · 2020Article
- Effectiveness of radioactive iodine (American journal of nuclear medicine and molecular imaging · 2020Article
- Assessing American Thyroid Association Guidelines for Total Thyroidectomy in Graves' Disease.The Journal of surgical research · 2020Article
- Comparative analysis of radioactive iodine versus thyroidectomy for definitive treatment of Graves disease.Surgery · 2017Article
- Thyroidectomy for Graves' disease in children: Indications and complications.Journal of pediatric surgery · 2016Article
- Response to Radioiodine Therapy for Thyrotoxicosis: Disparate Outcomes for an Indigenous Population.International journal of endocrinology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPersistent or recurrent hyperthyroidism after treatment with radioactive iodine (RAI) is common and many patients require either additional doses or surgery before they are cured. The purpose of this study was to identify patterns and predictors of failure of RAI in patients with hyperthyroidism.
methodsWe conducted a retrospective review of patients treated with RAI from 2007 to 2010. Failure of RAI was defined as receipt of additional dose(s) and/or total thyroidectomy. Using a Cox proportional hazards model, we conducted univariate analysis to identify factors associated with failure of RAI. A final multivariate model was then constructed with significant (p < 0.05) variables from the univariate analysis.
resultsOf the 325 patients analyzed, 74 patients (22.8 %) failed initial RAI treatment, 53 (71.6 %) received additional RAI, 13 (17.6 %) received additional RAI followed by surgery, and the remaining 8 (10.8 %) were cured after thyroidectomy. The percentage of patients who failed decreased in a stepwise fashion as RAI dose increased. Similarly, the incidence of failure increased as the presenting T3 level increased. Sensitivity analysis revealed that RAI doses <12.5 mCi were associated with failure while initial T3 and free T4 levels of at least 4.5 pg/mL and 2.3 ng/dL, respectively, were associated with failure. In the final multivariate analysis, higher T4 (hazard ratio [HR] 1.13; 95 % confidence interval [CI] 1.02-1.26; p = 0.02) and methimazole treatment (HR 2.55; 95 % CI 1.22-5.33; p = 0.01) were associated with failure.
conclusionsLaboratory values at presentation can predict which patients with hyperthyroidism are at risk for failing RAI treatment. Higher doses of RAI or surgical referral may prevent the need for repeat RAI in selected patients.
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