ArticleEnvironmental health perspectives2014
Associations between arsenic species in exfoliated urothelial cells and prevalence of diabetes among residents of Chihuahua, Mexico.
Article in Environmental health perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 58 citations in OpenAlex.
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- Mechanisms Associated with Cognitive and Behavioral Impairment Induced by Arsenic Exposure.Cells · 2023Review
- Arsenic metabolism, diabetes prevalence, and insulin resistance among Mexican Americans: A mendelian randomization approach.Environmental advances · 2023Article
- Article
- Ex vivo exposures to arsenite and its methylated trivalent metabolites alter gene transcription in mouse sperm cells.Toxicology and applied pharmacology · 2022Article
- The pharmacokinetics of therapeutic arsenic trioxide in acute promyelocytic leukemia patients.Leukemia & lymphoma · 2022Article
- Exploratory study of the association in the United Kingdom between hypertension and inorganic arsenic (iAs) intake from rice and rice products.Environmental geochemistry and health · 2021Article
- Origins, fate, and actions of methylated trivalent metabolites of inorganic arsenic: progress and prospects.Archives of toxicology · 2021Review
- Effects of Untreated Drinking Water at Three Indigenous Yaqui Towns in Mexico: Insights from a Murine Model.International journal of environmental research and public health · 2021Article
- Health effects of arsenic exposure in Latin America: An overview of the past eight years of research.The Science of the total environment · 2020Article
- Evaluation of plasma arsenicals as potential biomarkers of exposure to inorganic arsenic.Journal of exposure science & environmental epidemiology · 2019Article
- One-carbon metabolism nutrient intake and the association between body mass index and urinary arsenic metabolites in adults in the Chihuahua cohort.Environment international · 2019Article
- Circulating miRNAs Associated with Arsenic Exposure.Environmental science & technology · 2018Article
- Metabolic Phenotype of Wild-Type andEnvironmental health perspectives · 2018Article
- Direct Speciation Analysis of Arsenic in Whole Blood and Blood Plasma at Low Exposure Levels by Hydride Generation-Cryotrapping-Inductively Coupled Plasma Mass Spectrometry.Analytical chemistry · 2017Article
- Genotoxicity induced by monomethylarsonous acid (MMAToxicology letters · 2017Article
- Efflux Transporters Regulate Arsenite-Induced Genotoxicity in Double Negative and Double Positive T Cells.Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
- Genetic and epigenetic mechanisms underlying arsenic-associated diabetes mellitus: a perspective of the current evidence.Epigenomics · 2017Review
- The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study.Diabetes care · 2017Article
- Differential sensitivities of bone marrow, spleen and thymus to genotoxicity induced by environmentally relevant concentrations of arsenite.Toxicology letters · 2016Article
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Authors and funding
19 authors at 8 institutions in 5 countries.
Funding
Abstract
backgroundA growing number of studies link chronic exposure to inorganic arsenic (iAs) with the risk of diabetes. Many of these studies assessed iAs exposure by measuring arsenic (As) species in urine. However, this approach has been criticized because of uncertainties associated with renal function and urine dilution in diabetic individuals.
objectivesOur goal was to examine associations between the prevalence of diabetes and concentrations of As species in exfoliated urothelial cells (EUC) as an alternative to the measures of As in urine.
methodsWe measured concentrations of trivalent and pentavalent iAs methyl-As (MAs) and dimethyl-As (DMAs) species in EUC from 374 residents of Chihuahua, Mexico, who were exposed to iAs in drinking water. We used fasting plasma glucose, glucose tolerance tests, and self-reported diabetes diagnoses or medication to identify diabetic participants. Associations between As species in EUC and diabetes were estimated using logistic and linear regression, adjusting for age, sex, and body mass index.
resultsInterquartile-range increases in trivalent, but not pentavalent, As species in EUC were positively and significantly associated with diabetes, with ORs of 1.57 (95% CI: 1.19, 2.07) for iAsIII, 1.63 (1.24, 2.15) for MAsIII, and 1.31 (0.96, 1.84) for DMAsIII. DMAs/MAs and DMAs/iAs ratios were negatively associated with diabetes (OR = 0.62; 95% CI: 0.47, 0.83 and OR = 0.72; 95% CI: 0.55, 0.96, respectively).
conclusionsOur data suggest that uncertainties associated with measures of As species in urine may be avoided by using As species in EUC as markers of iAs exposure and metabolism. Our results provide additional support to previous findings suggesting that trivalent As species may be responsible for associations between diabetes and chronic iAs exposure.
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