ArticleCurrent opinion in microbiology2014
Metagenomic small molecule discovery methods.
Article in Current opinion in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Strategies for Actinobacteria Isolation, Cultivation, and Metabolite Production that Are Biologically Important.ACS omega · 2025Review
- Shotgun metagenomic insights into secondary metabolite biosynthetic gene clusters reveal taxonomic and functional profiles of microbiomes in natural farmland soil.Scientific reports · 2024Article
- Tapcin, an In Vivo Active Dual Topoisomerase I/II Inhibitor Discovered by Synthetic Bioinformatic Natural Product (Syn-BNP)-Coupled Metagenomics.Angewandte Chemie (International ed. in English) · 2024Article
- Chemical structure metagenomics of microbial natural products: surveying nonribosomal peptides and beyond.Beilstein journal of organic chemistry · 2024Article
- Present and future outlooks on environmental DNA-based methods for antibiotic discovery.Current opinion in microbiology · 2023Review
- Old and modern antibiotic structures with potential for today's infections.ADMET & DMPK · 2022Review
- Article
- Refactoring biosynthetic gene clusters for heterologous production of microbial natural products.Current opinion in biotechnology · 2021Review
- Recent Advances in Discovery of Lead Structures from Microbial Natural Products: Genomics- and Metabolomics-Guided Acceleration.Molecules (Basel, Switzerland) · 2021Review
- Synergizing the potential of bacterial genomics and metabolomics to find novel antibiotics.Chemical science · 2021Review
- Advanced Computational Methodologies Used in the Discovery of New Natural Anticancer Compounds.Frontiers in pharmacology · 2021Review
- Synthetic-Bioinformatic Natural Product Antibiotics with Diverse Modes of Action.Journal of the American Chemical Society · 2020Article
- Microfluidic automated plasmid library enrichment for biosynthetic gene cluster discovery.Nucleic acids research · 2020Article
- Diversity of Bacterial Biosynthetic Genes in Maritime Antarctica.Microorganisms · 2020Article
- Genome mining- and synthetic biology-enabled production of hypermodified peptides.Nature chemistry · 2019Article
- The hidden enzymology of bacterial natural product biosynthesis.Nature reviews. Chemistry · 2019Article
- Concepts and Methods to Access Novel Antibiotics from Actinomycetes.Antibiotics (Basel, Switzerland) · 2018Review
- ExoCET: exonuclease in vitro assembly combined with RecET recombination for highly efficient direct DNA cloning from complex genomes.Nucleic acids research · 2018Article
- Unique amalgamation of primary and secondary structural elements transform peptaibols into potent bioactive cell-penetrating peptides.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Natural product discovery from the human microbiome.The Journal of biological chemistry · 2017Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Metagenomic approaches to natural product discovery provide the means to harvest bioactive small molecules synthesized by environmental bacteria without the requirement of first culturing these organisms. Advances in sequencing technologies and general metagenomic methods are beginning to provide the tools necessary to unlock the unexplored biosynthetic potential encoded by the genomes of uncultured environmental bacteria. Here, we highlight recent advances in sequence-based and functional-based metagenomic approaches that promise to facilitate antibiotic discovery from diverse environmental microbiomes.
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Registered trials
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