ArticlePediatric research2014
Bifidobacterium longum subsp. infantis in experimental necrotizing enterocolitis: alterations in inflammation, innate immune response, and the microbiota.
Article in Pediatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Bifidobacterium infantis as a probiotic in preterm infants: a systematic review and meta-analysis.Pediatric research · 2023Pooled it
- Effects of probiotics on experimental necrotizing enterocolitis: a systematic review and meta-analysis.Pediatric research · 2018Pooled it
- Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms.PloS one · 2019Trial
- Association of single nucleotide polymorphisms of IL23R and IL17 with necrotizing enterocolitis in premature infants.Molecular and cellular biochemistry · 2017Trial
- Safety and tolerability of Bifidobacterium longum subspecies infantis EVC001 supplementation in healthy term breastfed infants: a phase I clinical trial.BMC pediatrics · 2017Trial
- Probiotic Administration in Infants With Gastroschisis: A Pilot Randomized Placebo-Controlled Trial.Journal of pediatric gastroenterology and nutrition · 2016Trial
- The microbiome's hidden influence: preclinical insights into inflammatory responses in necrotizing enterocolitis.Seminars in immunopathology · 2025Review
- Multi-strain probiotic administration decreases necrotizing enterocolitis severity and alters the epigenetic profile in mice.Pediatric research · 2025Article
- A multi-strain probiotic formulation preserves intestinal epithelial and vascular barriers during enteropathogenic infection.Frontiers in microbiology · 2025Article
- Immune microenvironment-dependent effects of age-associatedFrontiers in cellular and infection microbiology · 2025Article
- Impact ofNutrients · 2024Review
- Infant Microbiota Communities and Human Milk Oligosaccharide Supplementation Independently and Synergistically Shape Metabolite Production and Immune Responses in Healthy Mice.The Journal of nutrition · 2024Article
- Associations between impulsivity and fecal microbiota in individuals abstaining from methamphetamine.CNS neuroscience & therapeutics · 2024Article
- Molecular strategies for the utilisation of human milk oligosaccharides by infant gut-associated bacteria.FEMS microbiology reviews · 2023Review
- New insights into the pathogenesis of necrotizing enterocolitis and the dawn of potential therapeutics.Seminars in pediatric surgery · 2023Review
- Development of the Neonatal Intestinal Barrier, Microbiome, and Susceptibility to NEC.Microorganisms · 2023Review
- Beneficial Effects of ProbioticInternational journal of molecular sciences · 2023Article
- Review
- Current and future methods of probiotic therapy for necrotizing enterocolitis.Frontiers in pediatrics · 2023Review
- Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundProbiotics decrease the risk of necrotizing enterocolitis (NEC). We sought to determine the impact of Bifidobacterium longum subsp. infantis (B. infantis) in the established rat model of NEC.
methodsRat pups delivered 1 d prior to term gestation were assigned to one of three groups: dam fed (DF), formula fed (FF), or fed with formula supplemented with 5 × 10(6) CFU B. infantis per day (FF+Binf). Experimental pups were exposed to hypoxia and cold stress. Ileal tissue was examined for pathology and expression of inflammatory mediators, antimicrobial peptides, and goblet-cell products. Ceca were assessed for bacterial composition by analysis of the 16S rRNA sequence.
resultsAdministration of B. infantis significantly reduced the incidence of NEC, decreased expression of Il6, Cxcl1, Tnfa, Il23, and iNOS, and decreased expression of the antimicrobial peptides Reg3b and Reg3g. There was significant microbial heterogeneity both within groups and between experiments. The cecal microbiota was not significantly different between the FF and FF+Binf groups. Bifidobacteria were not detected in the cecum in significant numbers.
conclusionIn the rat model, the inflammation associated with NEC was attenuated by administration of probiotic B. infantis. Dysbiosis was highly variable, precluding determination of the precise role of the microbiota in experimental NEC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.