ReviewCurrent opinion in structural biology2014
The evolution of enzyme function in the isomerases.
Review in Current opinion in structural biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- Dynamic and Catalytic Multiphase Coacervates.Biomacromolecules · 2026Article
- Appraisal of biohydrogenating probiotic enzymes for the synthesis of conjugated linoleic acid isomers.Frontiers in microbiology · 2026Review
- Computational studies on the functional and structural impact of pathogenic mutations in enzymes.Protein science : a publication of the Protein Society · 2025Review
- Exploring the enzymatic repertoires of Bacteria and Archaea and their associations with metabolic maps.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Multidomain chimeric enzymes as a promising alternative for biocatalysts improvement: a minireview.Molecular biology reports · 2024Review
- Structural mechanism of a dual-functional enzyme DgpA/B/C as both aActa pharmaceutica Sinica. B · 2023Article
- Crystal structure and molecular mechanism of an E/F type bilin lyase-isomerase.Structure (London, England : 1993) · 2022Article
- Nano-evolution and protein-based enzymatic evolution predicts novel types of natural product nanozymes of traditional Chinese medicine: cases of herbzymes of Taishan-Huangjing (Nanoscale advances · 2021Article
- A roadmap for metagenomic enzyme discovery.Natural product reports · 2021Review
- The Role of Gene Duplication in the Divergence of Enzyme Function: A Comparative Approach.Frontiers in genetics · 2021Article
- CATH: expanding the horizons of structure-based functional annotations for genome sequences.Nucleic acids research · 2019Article
- To what extent do structural changes in catalytic metal sites affect enzyme function?Journal of inorganic biochemistry · 2018Article
- Assessing in silico the recruitment and functional spectrum of bacterial enzymes from secondary metabolism.BMC evolutionary biology · 2017Article
- Article
- Reaction Decoder Tool (RDT): extracting features from chemical reactions.Bioinformatics (Oxford, England) · 2016Article
- Exploring the chemistry and evolution of the isomerases.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Characterising Complex Enzyme Reaction Data.PloS one · 2016Article
- Diversity in protein domain superfamilies.Current opinion in genetics & development · 2015Review
- The Classification and Evolution of Enzyme Function.Biophysical journal · 2015Review
- Identification of Alp1U and Lom6 as epoxy hydrolases and implications for kinamycin and lomaiviticin biosynthesis.Nature communications · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
The advent of computational approaches to measure functional similarity between enzymes adds a new dimension to existing evolutionary studies based on sequence and structure. This paper reviews research efforts aiming to understand the evolution of enzyme function in superfamilies, presenting a novel strategy to provide an overview of the evolution of enzymes belonging to an individual EC class, using the isomerases as an exemplar.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.