Trial reportPloS one2014
BMI modulates calorie-dependent dopamine changes in accumbens from glucose intake.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Striatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgery: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- GLP-1 Receptor Agonist and GIP/GLP-1 Receptor Dual Agonist Therapeutics at the Intersection of Alcohol Use Disorder, Obesity, and Cardiometabolic Dysfunction.Biological psychiatry global open science · 2026Review
- When does post-ingestive dopamine signaling occur in humans?bioRxiv : the preprint server for biology · 2026Article
- Central dopamine receptors: Radiotracers unveiling the Role of dopaminergic tone in obesity.Journal of molecular medicine (Berlin, Germany) · 2025Review
- Brain dopamine responses to ultra-processed milkshakes are highly variable and not significantly related to adiposity in humans.medRxiv : the preprint server for health sciences · 2024Article
- Paediatric obesity and metabolic syndrome associations with cognition and the brain in youth: Current evidence and future directions.Pediatric obesity · 2023Review
- Molecular Imaging of Central Dopamine in Obesity: A Qualitative Review across Substrates and Radiotracers.Brain sciences · 2022Review
- Sex differences in methylphenidate-induced dopamine increases in ventral striatum.Molecular psychiatry · 2022Article
- Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study.Brain sciences · 2021Article
- Dopamine Modulation of Motor and Sensory Cortical Plasticity among Vertebrates.Integrative and comparative biology · 2021Review
- Fructose and Uric Acid as Drivers of a Hyperactive Foraging Response: A Clue to Behavioral Disorders Associated with Impulsivity or Mania?Evolution and human behavior : official journal of the Human Behavior and Evolution Society · 2021Article
- Neuroimaging of Sex/Gender Differences in Obesity: A Review of Structure, Function, and Neurotransmission.Nutrients · 2020Review
- Striatal Dopamine Responses to Feeding are Altered in People with Obesity.Obesity (Silver Spring, Md.) · 2020Article
- Time-dependent assessment of stimulus-evoked regional dopamine release.Nature communications · 2019Article
- The dopamine motive system: implications for drug and food addiction.Nature reviews. Neuroscience · 2017Review
- Phenotypes of Obesity: How it Impacts Management.Current gastroenterology reports · 2017Review
- High monetary reward rates and caloric rewards decrease temporal persistence.Proceedings. Biological sciences · 2017Article
- Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity.Cell metabolism · 2017Article
- Weight loss after bariatric surgery normalizes brain opioid receptors in morbid obesity.Molecular psychiatry · 2016Article
- Effects of the modern food environment on striatal function, cognition and regulation of ingestive behavior.Current opinion in behavioral sciences · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveDopamine mediates the rewarding effects of food that can lead to overeating and obesity, which then trigger metabolic neuroadaptations that further perpetuate excessive food consumption. We tested the hypothesis that the dopamine response to calorie intake (independent of palatability) in striatal brain regions is attenuated with increases in weight.
methodWe used positron emission tomography with [11C]raclopride to measure dopamine changes triggered by calorie intake by contrasting the effects of an artificial sweetener (sucralose) devoid of calories to that of glucose to assess their association with body mass index (BMI) in nineteen healthy participants (BMI range 21-35).
resultsNeither the measured blood glucose concentrations prior to the sucralose and the glucose challenge days, nor the glucose concentrations following the glucose challenge vary as a function of BMI. In contrast the dopamine changes in ventral striatum (assessed as changes in non-displaceable binding potential of [11C]raclopride) triggered by calorie intake (contrast glucose - sucralose) were significantly correlated with BMI (r = 0.68) indicating opposite responses in lean than in obese individuals. Specifically whereas in normal weight individuals (BMI <25) consumption of calories was associated with increases in dopamine in the ventral striatum in obese individuals it was associated with decreases in dopamine.
conclusionThese findings show reduced dopamine release in ventral striatum with calorie consumption in obese subjects, which might contribute to their excessive food intake to compensate for the deficit between the expected and the actual response to food consumption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.