ReviewInternational journal of molecular sciences2014
Bioactive coatings for orthopaedic implants-recent trends in development of implant coatings.
Review in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 382 citations in OpenAlex.
- Advances in the Application of Multimodal Nano-Antimicrobial Strategies in Prosthetic Joint Infections: A Systematic Review.International journal of nanomedicine · 2025Pooled it
- Biofilm formation associated with calcium phosphate coating on implant metals.Journal of materials science. Materials in medicine · 2026Article
- A novel strategy for secretory leukocyte protease inhibitor (SLPI) immobilization on alkaline-etched titanium via a plasma-polymerized interlayer and covalent coupling to enhance osteoblast activity.Scientific reports · 2026Article
- Effect of local administration of microRNA-31/210 on bone regeneration surrounding hydroxyapatite/tricalcium phosphate -coated titanium implant in an ovariectomized rat model.Regenerative therapy · 2026Article
- Enhanced crystallinity, hardness and thermal stability of PEEK/TC4 composites for biomedical applications.Scientific reports · 2026Article
- Electrochemical Deposition and Characterisation of Silver-Containing Hydroxyapatite Coatings on Zinc: Influence of Silver Addition on the Functional Properties of a Biodegradable Implant System.International journal of biomaterials · 2026Article
- An updated review and recent advancements in carbon-based bioactive coatings for dental implant applications.Journal of advanced research · 2025Review
- Advances of Hydroxyapatite Nanoparticles in Dental Implant Applications.International dental journal · 2025Review
- Application of custom-made joint prostheses in wrist.Journal of Zhejiang University. Science. B · 2025Review
- Effect of cobalt ions doping on morphology and electrochemical properties of hydroxyapatite coatings for biomedical applications.Scientific reports · 2025Article
- Calcium hydroxide coating for orthopedic implants: evaluation of osseointegrative and antibacterial propertiesFrontiers in bioengineering and biotechnology · 2025Article
- Analyzing antibacterial potential of bellamyaFrontiers in pharmacology · 2025Article
- Innovative Nanotechnological Approaches in Trauma and Orthopaedic Surgery: A Comprehensive Review.Cureus · 2024Review
- Organic-Inorganic Biocompatible Coatings for Temporary and Permanent Metal Implants.International journal of molecular sciences · 2024Review
- Suspension-Sprayed Calcium Phosphate Coatings with Antibacterial Properties.Journal of functional biomaterials · 2024Article
- Therapeutic Efficacy of an Erythromycin-Loaded Coaxial Nanofiber Coating in a Rat Model ofInternational journal of molecular sciences · 2024Article
- Optimizing alkaline hydrothermal treatment for biomimetic smart metallic orthopedic and dental implants.Journal of materials science. Materials in medicine · 2024Article
- Forged to heal: The role of metallic cellular solids in bone tissue engineering.Materials today. Bio · 2023Article
- In Vitro Characterization of an Anodized Surface of a Dental Implant Collar and Dental Abutment on Peri-Implant Cellular Response.Materials (Basel, Switzerland) · 2023Article
- Highly Adhesive Antimicrobial Coatings for External Fixation Devices.Gels (Basel, Switzerland) · 2023Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Joint replacement is a major orthopaedic procedure used to treat joint osteoarthritis. Aseptic loosening and infection are the two most significant causes of prosthetic implant failure. The ideal implant should be able to promote osteointegration, deter bacterial adhesion and minimize prosthetic infection. Recent developments in material science and cell biology have seen the development of new orthopaedic implant coatings to address these issues. Coatings consisting of bioceramics, extracellular matrix proteins, biological peptides or growth factors impart bioactivity and biocompatibility to the metallic surface of conventional orthopaedic prosthesis that promote bone ingrowth and differentiation of stem cells into osteoblasts leading to enhanced osteointegration of the implant. Furthermore, coatings such as silver, nitric oxide, antibiotics, antiseptics and antimicrobial peptides with anti-microbial properties have also been developed, which show promise in reducing bacterial adhesion and prosthetic infections. This review summarizes some of the recent developments in coatings for orthopaedic implants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.