ArticleACS synthetic biology2014
Cellular signaling circuits interfaced with synthetic, post-translational, negating Boolean logic devices.
Article in ACS synthetic biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Cell-free recombinase-integrated Boolean output system.Cell systems · 2025Article
- Synthetic control of actin polymerization and symmetry breaking in active protocells.Science advances · 2024Article
- Review
- Mechanobiology of immune cells: Messengers, receivers and followers in leishmaniasis aiding synthetic devices.Current research in immunology · 2022Review
- Dual Systems for Enhancing Control of Protein Activity through Induced Dimerization Approaches.Advanced biology · 2021Review
- High-performance chemical- and light-inducible recombinases in mammalian cells and mice.Nature communications · 2019Article
- Molecular tools for acute spatiotemporal manipulation of signal transduction.Current opinion in chemical biology · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A negating functionality is fundamental to information processing of logic circuits within cells and computers. Aiming to adapt unutilized electronic concepts to the interrogation of signaling circuits in cells, we first took a bottom-up strategy whereby we created protein-based devices that perform negating Boolean logic operations such as NOT, NOR, NAND, and N-IMPLY. These devices function in living cells within a minute by precisely commanding the localization of an activator molecule among three subcellular spaces. We networked these synthetic gates to an endogenous signaling circuit and devised a physiological output. In search of logic functions in signal transduction, we next took a top-down approach and computationally screened 108 signaling pathways to identify commonalities and differences between these biological pathways and electronic circuits. This combination of synthetic and systems approaches will guide us in developing foundations for deconstruction of intricate cell signaling, as well as construction of biomolecular computers.
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Registered trials
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