ArticleAnnals of coloproctology2014
Sphincter-Preserving Therapy for Treating a Chronic Anal Fissure: Long-term Outcomes.
Article in Annals of coloproctology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Gastrointestinal Uses of Botulinum Toxin.Handbook of experimental pharmacology · 2021Trial
- Fisurectomy and anoplasty with botulinum toxin injection in patients with chronic anal posterior fissure with hypertonia: a long-term evaluation.Updates in surgery · 2021Article
- Comparison of the effectiveness of two treatment modalities for chronic anal fissure: Botox versus sphincterotomy.Turkish journal of surgery · 2020Article
- High-dose versus low-dose botulinum toxin in anal fissure disease.Techniques in coloproctology · 2017Article
- Long-term outcomes of Botulinum toxin in the treatment of chronic anal fissure: 5 years of follow-up.United European gastroenterology journal · 2017Article
- Review
- Prospective multicenter observational trial on the safety and efficacy of LEVORAG® Emulgel in the treatment of acute and chronic anal fissure.Techniques in coloproctology · 2015Observational
- Treatment option for aged, multiparous women with a chronic anal fissure.Annals of coloproctology · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo estimate the risk of recurrent fissure in ano after sphincter preserving treatments.
methodsA retrospective case note review, combined with a telephone survey was conducted for all patients treated for a chronic anal fissure between 1998 and 2008.
resultsSix hundred and twelve patients (303 women: mean age, 39 years; range, 16-86 years) were treated for chronic anal fissure between 1998 and 2008. Topical diltiazem 2% was initially prescribed for 8 weeks. The fissure did not heal in 141 patients. These patients (61 women: mean age, 30 years; range, 15-86 years) were treated with 100 IU botulinum A toxin (Botox) injection combined with a fissurectomy under general anaesthesia. Thirty eight patients suffered a recurrence of their fissure within two years. Thirty-four healed with further medical or sphincter conserving surgical therapy while four required a lateral internal sphincterotomy.
conclusionThe vast majority of patients with chronic anal fissure can be treated with sphincter conserving treatments. This may require several interventions before healing can be achieved. Assessment for recurrence after 'conservative' treatments requires a minimum of two-year follow-up.
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