Evidence map›Paper›PMID 24999450›Full record

ArticleMeta gene2014

Variants in motilin, somatostatin and their receptor genes and risk of biliary tract cancers and stones in Shanghai, China.

Hong-Li Xu, Ann W Hsing, Jill Koshiol, Lisa W Chu, Jia-Rong Cheng, Jing Gao, Yu-Ting Tan, Bing-Sheng Wang, Ming-Chang Shen, Yu-Tang Gao

Open access · hybridAbstract read
In one paragraph

Article in Meta gene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Hong-Li XuDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China.
Ann W HsingCancer Prevention Institute of California, Fremont, CA 94538, USA ; Stanford Cancer Institute, Palo Alto, CA 94305, USA.
Jill KoshiolDivision of Cancer Epidemiology and Genetics, NCI/NIH/DHHS, Bethesda, MD 20892, USA.
Lisa W ChuCancer Prevention Institute of California, Fremont, CA 94538, USA ; Stanford Cancer Institute, Palo Alto, CA 94305, USA.
Jia-Rong ChengDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China.
Jing GaoDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China.
Yu-Ting TanDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China.
Bing-Sheng WangDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China ; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Ming-Chang ShenDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China ; Department of Pathology, Cancer Hospital, Fudan University, Shanghai 200032, China.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China.
Renji Hospital · CNShanghai Cancer Institute · CNDivision of Cancer Epidemiology and GeneticsPalo Alto Institute · USStanford Cancer Institute

Funding

Etiology of Biliary Tract CancerZIACP010218 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI KOSHIOL, JILL · 2011 to 2025
$30.4M
Intramural NIH HHS ZIA CP010218
6 · The paper itself

Abstract

Altered motility of the gallbladder can result in gallstone and cholecystitis, which are important risk factor for biliary tract cancer. Motilin (MLN) and somatostatin (SST) are known important modulators of gallbladder motility. To determine whether genetic variants in motilin, somatostatin, and their receptor genes are associated with the risk of biliary tract cancers and stones, nine tag-SNPs were determined in 439 biliary tract cancer cases (253 gallbladder, 133 extrahepatic bile duct and 53 ampulla of Vater cancer cases), 429 biliary stone cases, and 447 population controls in a population-based case-control study in Shanghai, China. We found that subjects with the

Indexed as

biliary tract cancergallstonegenetic susceptibilityMLN and MLNRSSTR2 and SSTR5

Identifiers

PMID24999450
PMCPMC4080205
OpenAlexW2044267813

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.