ArticleImmunity & ageing : I & A2014
Impact of ageing on the response and repertoire of influenza virus-specific CD4 T cells.
Article in Immunity & ageing : I & A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Aging and Viral Evolution Impair Immunity Against Dominant Pan-Coronavirus-Reactive T Cell Epitope.European journal of immunology · 2025Article
- Characterisation of specific responses to three models of viral antigens in immunocompetent older adults.Immunity & ageing : I & A · 2024Article
- A spatial sequencing atlas of age-induced changes in the lung during influenza infection.Nature communications · 2023Article
- Decreased resistance to bacterial cold-water disease and excessive inflammatory response in ayu (Frontiers in immunology · 2023Article
- Cellular Senescence in Immunity against Infections.International journal of molecular sciences · 2022Review
- Review
- The temporal course of T- and B-cell responses to vaccination with BNT162b2 and mRNA-1273.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022Article
- CHIP-associated mutant ASXL1 in blood cells promotes solid tumor progression.Cancer science · 2022Article
- Immunity to acute virus infections with advanced age.Current opinion in virology · 2021Review
- Low-Avidity CD4Immunity · 2020Article
- Assessment of Lymph Node Stromal Cells as an Underlying Factor in Age-Related Immune Impairment.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly people.Immunity & ageing : I & A · 2019Article
- The impact of aging on CD4Biogerontology · 2018Review
- Cytomegalovirus (CMV) Epitope-Specific CD4Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Age- and Sex-associated Differences in Phenotypic and Functional Characteristics of Peripheral Blood Lymphocytes in Chimpanzees (Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Article
- Age Impacts Pulmonary Inflammation and Systemic Bone Response to Inhaled Organic Dust Exposure.Journal of toxicology and environmental health. Part A · 2015Article
- The Impact of Immunosenescence on Pulmonary Disease.Mediators of inflammation · 2015Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAgeing has been shown to reduce CD8 T cell repertoire diversity and immune responses against influenza virus infection in mice. In contrast, less is known about the impact of ageing on CD4 T cell repertoire diversity and immune response to influenza virus infection.
resultsThe CD4 T cell response was followed after infection of young and aged C57BL/6 mice with influenza virus using a tetramer specific for an immunodominant MHC class II epitope of the influenza virus nucleoprotein. The appearance of virus-specific CD4 T cells in the lung airways of aged mice was delayed compared to young mice, but the overall peak number and cytokine secretion profile of responding CD4 T cells was not greatly perturbed. In addition, the T cell repertoire of responding cells, determined using T cell receptor Vβ analysis, failed to show the profound effect of age we previously described for CD8 T cells. The reduced impact of age on influenza-specific CD4 T cells was consistent with a reduced effect of age on the overall CD4 compared with the CD8 T cell repertoire in specific pathogen free mice. Aged mice that were thymectomized as young adults showed an enhanced loss of the epitope-specific CD4 T cell response after influenza virus infection compared with age-matched sham-thymectomized mice, suggesting that a reduced repertoire can contribute to impaired responsiveness.
conclusionsThe diversity of the CD4 T cell repertoire and response to influenza virus is not as profoundly impaired by ageing in C57BL/6 mice as previously shown for CD8 T cells. However, adult thymectomy enhanced the impact of ageing on the response. Understanding the impact of ageing on CD4 T cell responses to influenza virus infection is an important prerequisite for developing better vaccines for the elderly.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.