Evidence map›Paper›PMID 24999318›Full record

ReviewFrontiers in cellular neuroscience2014

Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling.

Cristy Phillips, Mehmet Akif Baktir, Malathi Srivatsan, Ahmad Salehi

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04944251 (Exercise in Persons With Multiple Sclerosis), which is not on this map. Cited by 138 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 6 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04944251 nacompletednot on this mapstarted 2019, after this paper: background citation

Exercise in Persons With Multiple Sclerosis

TypeinterventionalSponsorEge UniversityRan2019 to 2020Enrolled43ConditionsMultiple Sclerosis, Exercise Intervention, Neuro-Degenerative DiseaseArmsRegular Exercise
3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 6 syntheses or guidelines pooled it, 325 citations in OpenAlex.

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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Cristy PhillipsDepartment of Physical Therapy, Arkansas State University Jonesboro, AR, USA.
Mehmet Akif BaktirDepartment of Physiology, Erciyes University Kayseri, Turkey; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.
Malathi SrivatsanDepartment of Biological Sciences, Arkansas State University Jonesboro, AR, USA
Ahmad SalehiVA Palo Alto Health Care System Palo Alto, CA, USA.
Arkansas State University · USErciyes University · TRStanford University · USVA Palo Alto Health Care System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the relationship between increased physical activity and cognitive ability has been conjectured for centuries, only recently have the mechanisms underlying this relationship began to emerge. Convergent evidence suggests that physical activity offers an affordable and effective method to improve cognitive function in all ages, particularly the elderly who are most vulnerable to neurodegenerative disorders. In addition to improving cardiac and immune function, physical activity alters trophic factor signaling and, in turn, neuronal function and structure in areas critical for cognition. Sustained exercise plays a role in modulating anti-inflammatory effects and may play a role in preserving cognitive function in aging and neuropathological conditions. Moreover, recent evidence suggests that myokines released by exercising muscles affect the expression of brain-derived neurotrophic factor synthesis in the dentate gyrus of the hippocampus, a finding that could lead to the identification of new and therapeutically important mediating factors. Given the growing number of individuals with cognitive impairments worldwide, a better understanding of how these factors contribute to cognition is imperative, and constitutes an important first step toward developing non-pharmacological therapeutic strategies to improve cognition in vulnerable populations.

Indexed as

brain-derived neurotrophic factorFNDC5Irisinmyokinesneurotrophinsphysical activityVal66Met

Identifiers

PMID24999318
PMCPMC4064707
OpenAlexW2097515789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.