ArticleAdvanced functional materials2013
A fabricated siRNA nanoparticle for ultra-long gene silencing
Article in Advanced functional materials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Solution Conditions Tune and Optimize Loading of Therapeutic Polyelectrolytes into Layer-by-Layer Functionalized Liposomes.ACS nano · 2019Article
- Nanoparticle Delivery of miR-708 Mimetic Impairs Breast Cancer Metastasis.Molecular cancer therapeutics · 2019Article
- Versatile Nanodelivery Platform to Maximize siRNA Combination Therapy.Macromolecular bioscience · 2017Article
- Composite vector formulation for multiple siRNA delivery as a host targeting antiviral in a cell culture model of hepatitis C virus (HCV) infection.Journal of materials chemistry. B · 2017Article
- Progress and perspective of inorganic nanoparticle-based siRNA delivery systems.Expert opinion on drug delivery · 2016Review
- An authentic imaging probe to track cell fate from beginning to end.Nature communications · 2014Article
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Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Persistent gene silencing is crucially required for the successful therapeutics of short interfering RNA (siRNA). Here, we describe a nanoparticle based delivery system which assembled by layering siRNAs between protease degradable polypeptides to extend the therapeutic window. These tightly packed nanoparticles are efficiently taken up by cells by endocytosis, and the fabricated siRNAs are gradually released following intracellular degradation of the polypeptide layers. During cell division, the particles are distributed to the daughter cells. Due to the slow degradation through the multiple layers, the particles continuously release siRNA in all cells. Using this controlled release construct, the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.