ArticleBiological procedures online2014
A novel model of appendicitis and appendectomy to investigate inflammatory bowel disease pathogenesis and remediation.
Article in Biological procedures online, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Effect of Endoscopic Retrograde Appendicitis Therapy on Postoperative Gastrointestinal Function in Patients With Chronic Fecalith Appendicitis.Gastroenterology research and practice · 2026Article
- Environmental and Microbial Factors in Inflammatory Bowel Disease Model Establishment: A Review Partly through Mendelian Randomization.Gut and liver · 2024Review
- Markers of neutrophil activation and extracellular traps formation are predictive of appendicitis in mice and humans: a pilot study.Scientific reports · 2020Article
- The Role of Specific Chemokines in the Amelioration of Colitis by Appendicitis and Appendectomy.Biomolecules · 2018Article
- Potential role for ET-2 acting through ETA receptors in experimental colitis in mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Article
- Modulation of interferon activity-associated soluble molecules by appendicitis and appendectomy limits colitis-identification of novel anti-colitic targets.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2015Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The appendix contains copious lymphoid tissue and is constantly exposed to gut flora. Appendicitis and appendectomy (AA) has been shown to prevent or significantly ameliorate ulcerative colitis. In our novel murine AA model, the only existing experimental model of AA, the appendiceal pathology closely resembles that of human appendicitis; and AA offers an age-, bacteria- and antigen-dependent protection against colitis. Appendicitis and appendectomy performed in the most proximal colon curbs T helper 17 cell activity, curtails autophagy, modulates interferon activity-associated molecules, and suppresses endothelin vasoactivity-mediated immunopathology/vascular remodelling in the most distal colon . These AA-induced changes contribute to the limitation/amelioration of colitis pathology. Investigating strategies to manipulate and modulate different aspects of these pathways (using monoclonal antibodies, combinatorial peptides, and small molecules) would offer novel insight into inflammatory bowel disease pathogenesis, and will augment the development of new therapeutic options to manage recalcitrant colitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.