Evidence map›Paper›PMID 24999044›Full record

ReviewVirology2014

Quantitative real-time single particle analysis of virions.

Susanne Heider, Christoph Metzner

Abstract readReview
In one paragraph

Review in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Susanne HeiderInstitute of Virology, University of Veterinary Medicine Vienna, Building AC, 3rd Floor, Veterinärplatz 1, 1210 Vienna, Austria.
Christoph MetznerInstitute of Virology, University of Veterinary Medicine Vienna, Building AC, 3rd Floor, Veterinärplatz 1, 1210 Vienna, Austria. Electronic address: christoph.metzner@vetmeduni.ac.at.

Funding

Austrian Science Fund FWF P 25297
6 · The paper itself

Abstract

Providing information about single virus particles has for a long time been mainly the domain of electron microscopy. More recently, technologies have been developed-or adapted from other fields, such as nanotechnology-to allow for the real-time quantification of physical virion particles, while supplying additional information such as particle diameter concomitantly. These technologies have progressed to the stage of commercialization increasing the speed of viral titer measurements from hours to minutes, thus providing a significant advantage for many aspects of virology research and biotechnology applications. Additional advantages lie in the broad spectrum of virus species that may be measured and the possibility to determine the ratio of infectious to total particles. A series of disadvantages remain associated with these technologies, such as a low specificity for viral particles. In this review we will discuss these technologies by comparing four systems for real-time single virus particle analysis and quantification.

Indexed as

NanotechnologyViral LoadVirionFlow-field-fractionationMultiple-angle laser light scanningNanoparticle tracking analysisNanoSightSingle particle analysisTunable resitive pulse sensingVirusCounterVirus titer

Identifiers

PMID24999044
PMCPMC4139191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.