ArticleJournal of biomechanics2014
Validation and application of an intervertebral disc finite element model utilizing independently constructed tissue-level constitutive formulations that are nonlinear, anisotropic, and time-dependent.
Article in Journal of biomechanics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Asymmetric cement distribution in the coronal plane increases the risk of prosthetic loosening following total knee arthroplasty: an in-silico study.BMC surgery · 2026Article
- Modeling Fatigue and Damage Development in the Annulus Fibrosus Using a Reactive Viscoelastic Framework.Annals of biomedical engineering · 2026Article
- Finite element models of intervertebral disc: recent advances and prospects.Annals of medicine · 2025Review
- Wider screw spread can reduce the risk of short-term femoral head necrosis by optimizing the fixation stability in femoral neck fracture patients with triangle cannulated screw fixation.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- Sagittal-oriented articular processes and intervertebral disc degeneration phenotypes can concurrently lead to an increased presence of annulus tears in the cranial adjacent motion segment : a clinical review and biomechanical simulation.Bone & joint research · 2025Article
- Article
- An OLIF Cage Integrated with a Low-Profile Plate and Cross Screws Could Reduce the Risk of Postoperative Complications Biomechanically.Annals of biomedical engineering · 2025Article
- Biomechanics of soft biological tissues and organs, mechanobiology, homeostasis and modelling.Journal of the Royal Society, Interface · 2025Review
- Global and local identifiability analysis of a nonlinear biphasic constitutive model in confined compression.Journal of the Royal Society, Interface · 2024Article
- Article
- Geometric determinants of the mechanical behavior of image-based finite element models of the intervertebral disc.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Intraoperative capsule protection can reduce the potential risk of adjacent segment degeneration acceleration biomechanically: an in silico study.Journal of orthopaedic surgery and research · 2024Article
- Annulus Calibration Increases the Computational Accuracy of the Lumbar Finite Element Model.Global spine journal · 2023Article
- Development of a Computational Model of the Mechanical Behavior of the L4-L5 Lumbar Spine: Application to Disc Degeneration.Materials (Basel, Switzerland) · 2022Article
- Low-Modulus PMMA Has the Potential to Reduce Stresses on Endplates after Cement Discoplasty.Journal of functional biomaterials · 2022Article
- Biphasic Properties of PVAH (Polyvinyl Alcohol Hydrogel) Reflecting Biomechanical Behavior of the Nucleus Pulposus of the Human Intervertebral Disc.Materials (Basel, Switzerland) · 2022Article
- Will the adjustment of insertional pedicle screw positions affect the risk of adjacent segment diseases biomechanically? An in-silico study.Frontiers in surgery · 2022Article
- The Mismatch Between Bony Endplates and Grafted Bone Increases Screw Loosening Risk for OLIF Patients With ALSR Fixation Biomechanically.Frontiers in bioengineering and biotechnology · 2022Article
- Deterioration of the fixation segment's stress distribution and the strength reduction of screw holding position together cause screw loosening in ALSR fixed OLIF patients with poor BMD.Frontiers in bioengineering and biotechnology · 2022Article
- Multiaxial validation of a finite element model of the intervertebral disc with multigenerational fibers to establish residual strain.JOR spine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Finite element (FE) models are advantageous in the study of intervertebral disc mechanics as the stress-strain distributions can be determined throughout the tissue and the applied loading and material properties can be controlled and modified. However, the complicated nature of the disc presents a challenge in developing an accurate and predictive disc model, which has led to limitations in FE geometry, material constitutive models and properties, and model validation. The objective of this study was to develop a new FE model of the intervertebral disc, to validate the model's nonlinear and time-dependent responses without tuning or calibration, and to evaluate the effect of changes in nucleus pulposus (NP), cartilaginous endplate (CEP), and annulus fibrosus (AF) material properties on the disc mechanical response. The new FE disc model utilized an analytically-based geometry. The model was created from the mean shape of human L4/L5 discs, measured from high-resolution 3D MR images and averaged using signed distance functions. Structural hyperelastic constitutive models were used in conjunction with biphasic-swelling theory to obtain material properties from recent tissue tests in confined compression and uniaxial tension. The FE disc model predictions fit within the experimental range (mean ± 95% confidence interval) of the disc's nonlinear response for compressive slow loading ramp, creep, and stress-relaxation simulations. Changes in NP and CEP properties affected the neutral-zone displacement but had little effect on the final stiffness during slow-ramp compression loading. These results highlight the need to validate FE models using the disc's full nonlinear response in multiple loading scenarios.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.