ArticleAnnals of clinical microbiology and antimicrobials2014
Antifungal activity of synthetic naphthoquinones against dermatophytes and opportunistic fungi: preliminary mechanism-of-action tests.
Article in Annals of clinical microbiology and antimicrobials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Antifungal Activity of Selected Naphthoquinones and Their Synergistic Combination with Amphotericin B AgainstAntibiotics (Basel, Switzerland) · 2025Article
- Antifungal potential, mechanism of action, and toxicity of 1,4-naphthoquinone derivatives.European journal of microbiology & immunology · 2024Article
- Naphthoquinones as a Promising Class of Compounds for Facing the Challenge of Parkinson's Disease.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Searching for new antifungals for the treatment of cryptococcosis.Revista da Sociedade Brasileira de Medicina Tropical · 2023Review
- In Vitro Antimicrobial Effects and Inactivation Mechanisms of 5,8-Dihydroxy-1,4-Napthoquinone.Antibiotics (Basel, Switzerland) · 2022Article
- Novel Solid Dispersions of Naphthoquinone Using Different Polymers for Improvement of Antichagasic Activity.Pharmaceutics · 2020Article
- Fungal Pigments: Potential Coloring Compounds for Wide Ranging Applications in Textile Dyeing.Journal of fungi (Basel, Switzerland) · 2020Review
- Toward a clinical antifungal peptoid: Investigations into the therapeutic potential of AEC5.Biopolymers · 2019Article
- Synthesis, Stability Studies, and Antifungal Evaluation of Substituted α- and β-2,3-Dihydrofuranaphthoquinones againstMolecules (Basel, Switzerland) · 2019Article
- Screening and Antifungal Activity of aInternational journal of microbiology · 2019Article
- Characterization and Trypanocidal Activity of a Novel Pyranaphthoquinone.Molecules (Basel, Switzerland) · 2017Article
- Antimicrobial, antioxidant, toxicity and phytochemical assessment of extracts from Acmella uliginosa, a leafy-vegetable consumed in Bénin, West Africa.BMC complementary and alternative medicine · 2016Article
- A new and efficient procedure for the synthesis of hexahydropyrimidine-fused 1,4-naphthoquinones.Beilstein journal of organic chemistry · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study evaluated the antifungal activities of synthetic naphthoquinones against opportunistic and dermatophytic fungi and their preliminary mechanisms of action. The minimum inhibitory concentrations (MICs) of four synthetic naphthoquinones for 89 microorganisms, including opportunistic yeast agents, dermatophytes and opportunistic filamentous fungi, were determined. The compound that exhibited the best activity was assessed for its action against the cell wall (sorbitol test), for interference associated with ergosterol interaction, for osmotic balance (K+ efflux) and for membrane leakage of substances that absorb at the wavelength of 260 nm. All tested naphthoquinones exhibited antifungal activity, and compound IVS320 (3a,10b-dihydro-1H-cyclopenta [b] naphtho [2,3-d] furan-5,10-dione)-dione) demonstrated the lowest MICs across the tested species. The MIC of IVS320 was particularly low for dermatophytes (values ranging from 5-28 μg/mL) and Cryptococcus spp. (3-5 μg/mL). In preliminary mechanism-of-action tests, IVS320 did not alter the fungal cell wall but did cause problems in terms of cell membrane permeability (efflux of K+ and leakage of substances that absorb at 260 nm). This last effect was unrelated to ergosterol interactions with the membrane.
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