Evidence map›Paper›PMID 24998932›Full record

ArticleScientific reports2014

One-step shell polymerization of inorganic nanoparticles and their applications in SERS/nonlinear optical imaging, drug delivery, and catalysis.

Tzu-Ming Liu, Jiashing Yu, C Allen Chang, Arthur Chiou, Huihua Kenny Chiang, Yu-Chun Chuang, Cheng-Han Wu, Che-Hao Hsu, Po-An Chen, Chih-Chia Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Tzu-Ming Liu1] Institute of Biomedical Engineering and Molecular Imaging Center, National Taiwan University, Taipei, 106, Taiwan [2].
Jiashing Yu1] Department of Chemical Engineering, National Taiwan University, Taipei, 106, Taiwan [2].
C Allen Chang1] Department of Biomedical Imaging and Radiological Sciences National Yang-Ming University, Taipei, 112, Taiwan [2] Institute of Biophotonics, National Yang-Ming University, Taipei, 112, Taiwan [3] Biophotonics and Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei, 112, Taiwan.
Arthur Chiou1] Institute of Biophotonics, National Yang-Ming University, Taipei, 112, Taiwan [2] Biophotonics and Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei, 112, Taiwan.
Huihua Kenny Chiang1] Institute of Biophotonics, National Yang-Ming University, Taipei, 112, Taiwan [2] Biophotonics and Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei, 112, Taiwan [3] Institute of Biomedical Engineering, National Yang-Ming University, Taipei, 112, Taiwan.
Yu-Chun ChuangNational Synchrotron Radiation Research Center, Hsinchu, 300, Taiwan.
Cheng-Han WuInstitute of Biomedical Engineering and Molecular Imaging Center, National Taiwan University, Taipei, 106, Taiwan.
Che-Hao HsuDepartment of Chemical Engineering, National Taiwan University, Taipei, 106, Taiwan.
Po-An ChenInstitute of Biophotonics, National Yang-Ming University, Taipei, 112, Taiwan.
Chih-Chia Huang1] Institute of Biophotonics, National Yang-Ming University, Taipei, 112, Taiwan [2] Biophotonics and Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei, 112, Taiwan [3] Department of Applied Chemistry, National University of Kaohsiung, Kaohsiung, 811, Taiwan.
National Yang Ming Chiao Tung University · TWNational Taiwan University · TWNational Synchrotron Radiation Research Center · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surface functionalized nanoparticles have found their applications in several fields including biophotonics, nanobiomedicine, biosensing, drug delivery, and catalysis. Quite often, the nanoparticle surfaces must be post-coated with organic or inorganic layers during the synthesis before use. This work reports a generally one-pot synthesis method for the preparation of various inorganic-organic core-shell nanostructures (Au@polymer, Ag@polymer, Cu@polymer, Fe3O4@polymer, and TiO2@polymer), which led to new optical, magnetic, and catalytic applications. This green synthesis involved reacting inorganic precursors and poly(styrene-alt-maleic acid). The polystyrene blocks separated from the external aqueous environment acting as a hydrophobic depot for aromatic drugs and thus illustrated the integration of functional nanoobjects for drug delivery. Among these nanocomposites, the Au@polymer nanoparticles with good biocompatibility exhibited shell-dependent signal enhancement in the surface plasmon resonance shift, nonlinear fluorescence, and surface-enhanced Raman scattering properties. These unique optical properties were used for dual-modality imaging on the delivery of the aromatic photosensitizer for photodynamic therapy to HeLa cells.

Indexed as

Antineoplastic AgentsCatalysisDrug Screening Assays, AntitumorGoldGreen Chemistry TechnologyHeLa CellsHumansMagnetite NanoparticlesNanocapsulesNanocompositesOptical ImagingPhotosensitizing AgentsPolymerizationPolystyrenesSilverTitaniumAntineoplastic AgentsGoldMagnetite NanoparticlesNanocapsulesPhotosensitizing AgentsPolystyrenesSilverTitaniumtitanium dioxide

Identifiers

PMID24998932
PMCPMC4083277
OpenAlexW2082016750

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.