Evidence map›Paper›PMID 24998619›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015

Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder.

Stephanie M Gorka, Daniel A Fitzgerald, Izelle Labuschagne, Avinash Hosanagar, Amanda G Wood, Pradeep J Nathan, K Luan Phan

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 4 pooled it
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 4 syntheses or guidelines pooled it, 130 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pharmacotherapy for social anxiety disorder (SAnD).The Cochrane database of systematic reviews · 2017
    Pooled it
  5. Trial
  6. Trial
  7. Trial
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  10. Trial
  11. Trial
  12. Oxytocin increases eye gaze in schizophrenia.Schizophrenia research · 2019
    Trial
  13. Placebo treatment facilitates social trust and approach behavior.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Trial
  14. Trial
  15. Trial
  16. Intranasal Oxytocin Affects Amygdala Functional Connectivity after Trauma Script-Driven Imagery in Distressed Recently Trauma-Exposed Individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
    Trial
  17. Oxytocin Facilitates Pavlovian Fear Learning in Males.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
    Trial
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Stephanie M Gorka1] Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA [2] Department of Psychology, University of Illinois at Chicago, Chicago, IL, USA.
Daniel A Fitzgerald1] Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA [2] Mental Health Service Line, Jesse Brown VA Medical Center, Chicago, IL, USA.
Izelle Labuschagne1] School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia [2] School of Psychology, Australian Catholic University, Melbourne, Victoria, Australia.
Avinash Hosanagar1] Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA [2] Mental Health Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Amanda G Wood1] School of Psychology, University of Birmingham, Birmingham, UK [2] Child Neuropsychology, Murdoch Children's Research Institute, Melbourne, Victoria, Australia [3] Southern Clinical School, Monash University, Melbourne, Victoria, Australia.
Pradeep J Nathan1] School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia [2] Department of Psychiatry, University of Cambridge, Cambridge, UK.
K Luan Phan1] Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA [2] Department of Psychology, University of Illinois at Chicago, Chicago, IL, USA [3] Mental Health Service Line, Jesse Brown VA Medical Center, Chicago, IL, USA.
University of Illinois Chicago · USAustralian Catholic University · AUUniversity of Birmingham · GBUniversity of Cambridge · GBUniversity of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neuropeptide oxytocin (OXT) is thought to attenuate anxiety by dampening amygdala reactivity to threat in individuals with generalized social anxiety disorder (GSAD). Because the brain is organized into networks of interconnected areas, it is likely that OXT impacts functional coupling between the amygdala and other socio-emotional areas of the brain. Therefore, the aim of the current study was to examine the effects of OXT on amygdala functional connectivity during the processing of fearful faces in GSAD subjects and healthy controls (HCs). In a randomized, double-blind, placebo (PBO)-controlled, within-subjects design, 18 HCs and 17 GSAD subjects performed a functional magnetic resonance imaging task designed to probe amygdala response to fearful faces following acute intranasal administration of PBO or OXT. Functional connectivity between the amygdala and the rest of the brain was compared between OXT and PBO sessions using generalized psychophysiological interaction analyses. Results indicated that within individuals with GSAD, but not HCs, OXT enhanced functional connectivity between the amygdala and the bilateral insula and middle cingulate/dorsal anterior cingulate gyrus during the processing of fearful faces. These findings suggest that OXT may have broad pro-social implications such as enhancing the integration and modulation of social responses.

Indexed as

Facial ExpressionAdultAmygdalaAnti-Anxiety AgentsAnxiety DisordersBrain MappingDouble-Blind MethodFaceFacial RecognitionHumansMagnetic Resonance ImagingMaleNeural PathwaysNeuropsychological TestsOxytocinPhotic StimulationAnti-Anxiety AgentsOxytocin

Identifiers

PMID24998619
PMCPMC4443941
OpenAlexW2143428277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.