ArticleBMC complementary and alternative medicine2014
Dissection of the mechanism of traditional Chinese medical prescription-Yiqihuoxue formula as an effective anti-fibrotic treatment for systemic sclerosis.
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Clinical Efficacy and Safety of Bathing with Chinese Medicine Taohong Siwu Decoction () for Treatment of Diffuse Cutaneous Systemic Sclerosis: A Randomized Placebo-Controlled Trial.Chinese journal of integrative medicine · 2018Trial
- Mechanisms of autophagy and their implications in dermatological disorders.Frontiers in immunology · 2024Review
- ESRRB Inhibits the TGFβ Signaling Pathway to Drive Cell Proliferation in Cervical Cancer.Cancer research · 2023Article
- Care patterns and Traditional Chinese Medicine constitution as factors of depression and anxiety in patients with systemic sclerosis: A cross-sectional study during the COVID-19 pandemic.Frontiers in integrative neuroscience · 2023Article
- Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment.Research (Washington, D.C.) · 2023Article
- Icaritin Inhibits Skin Fibrosis through Regulating AMPK and Wnt/β-catenin Signaling.Cell biochemistry and biophysics · 2021Article
- Yiqi Huoxue Recipe Delayed Intervertebral Disc Degeneration by Activating Autophagy.Frontiers in pharmacology · 2021Article
- [Expression of pituitary tumor-transforming gene-1 and its pathogenic role in systemic sclerosis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- [Expression of calponin-1 and its pathogenic role in systemic sclerosis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Bufei Qingyu Granules Inhibit the Development of Systemic Sclerosis via Notch-1/Jagged-2 Signaling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Sirtuin1 Protects against Systemic Sclerosis-related Pulmonary Fibrosis by Decreasing Proinflammatory and Profibrotic Processes.American journal of respiratory cell and molecular biology · 2018Article
- Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model.Chinese medicine · 2018Article
- MiR-3606-3p inhibits systemic sclerosis through targeting TGF-β type II receptor.Cell cycle (Georgetown, Tex.) · 2018Article
- Treatment effects of the traditional Chinese medicine Shenks in bleomycin-induced lung fibrosis through regulation of TGF-beta/Smad3 signaling and oxidative stress.Scientific reports · 2017Article
- Salvianolic Acid B Attenuates Experimental Pulmonary Fibrosis through Inhibition of the TGF-β Signaling Pathway.Scientific reports · 2016Article
- Wenyang Huazhuo Tongluo formula, a Chinese herbal decoction, improves skin fibrosis by promoting apoptosis and inhibiting proliferation through down-regulation of survivin and cyclin D1 in systemic sclerosis.BMC complementary and alternative medicine · 2016Article
- Involvement of collagen-binding heat shock protein 47 in scleroderma-associated fibrosis.Protein & cell · 2015Article
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundSystemic sclerosis (SSc) is a connective tissue fibrotic disease for which there is no effective treatment. Traditional Chinese Medicine (TCM), such as the Yiqihuoxue formula used in Shanghai TCM-integrated Hospital, has shown the efficacy of anti-fibrosis in clinical applications. This study was aiming to dissect the anti-fibrotic mechanism of Yiqihuoxue treatment for SSc.
methodsBleomycin-induced mice and SSc dermal fibroblasts were treated with Yiqihuoxue decoction; NIH-3T3 fibroblasts were exposed to exogenous TGF-β1, and then cultured with or without Yiqihuoxue decoction. Luciferase reporter gene assay was used to determine the activity of Smad binding element (SBE). Quantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to examine the mRNA levels of extracellular matrix (ECM) genes. The protein levels of type I collagen, Smad3 and phosphorylated-Smad3 (p-Smad3) were detected by western blotting. Student's t-tests were used to determine the significance of the results.
resultsBleomycin-induced mice, SSc dermal fibroblasts and TGF-β1-induced NIH/3T3 fibroblasts showed higher levels of ECM gene transcriptions and collagen production. In addition, the phosphorylation level of Smad3 and activity of SBE were significantly increased after exogenous TGF-β1 induction. Whereas, Yiqihuoxue treatment could obviously attenuate fibrosis in bleomycin-induced mice, down regulate ECM gene expressions and collagen production in SSc dermal fibroblasts and TGF-β1-induced NIH/3T3 fibroblasts. Furthermore, the aberrantly high phosphorylation level of Smad3 and activity of SBE in the TGF-β1-induced NIH/3T3 fibroblasts were also dramatically decreased by Yiqihuoxue treatment.
conclusionsYiqihuoxue treatment could effectively reduce collagen production via down-regulating the phosphorylation of Smad3 and then the activity of SBE, which are involved in the TGF-β pathway and constitutively activated in the progression of SSc.
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