ArticleNature neuroscience2014
Noninvasive optical inhibition with a red-shifted microbial rhodopsin.
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In one paragraph
Article in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 306 papers, 1 of them a synthesis that pooled it.
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306citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 42% of its field
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Who cites it
306 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- A Systematic Review of Optogenetic Vision Restoration: History, Challenges, and New Inventions from Bench to Bedside.Cold Spring Harbor perspectives in medicine · 2023Pooled it
- Navigational strategy dictates hippocampal representation of space in an everyday memory task.Nature communications · 2026Article
- Crosstalk-free optical indicator-actuator combinations for bidirectional optogenetics.npj biomedical innovations · 2026Review
- The emergence of a novel CA1 spatial map requires direct entorhinal input.bioRxiv : the preprint server for biology · 2026Article
- Complementary roles of cell-type-specific plasticity in shaping neocortical dynamics for learning action timing.Nature communications · 2026Article
- Noninvasive optogenetic induction of cardiac arrhythmias alters systemic hemodynamics in mice.Science advances · 2026Article
- X-optogenetic inhibition of VTA GABA neurons for wireless deep-brain stimulation and suppression of scratching behavior in freely moving mice.Materials today. Bio · 2026Article
- Context-dependent effects of SOM neurons to enhance the responses of corticocollicular neurons to repetitive sounds.iScience · 2026Article
- Multimodal Optical Imaging and Modulation with Simultaneous Electrophysiology Through Smart Dura in Non-Human Primates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Projection-specific intersectional optogenetics for precise excitation and inhibition in the marmoset brain.Cell reports methods · 2026Article
- Ultrasound-Assisted multimodal neuromodulation via nanosystems.Journal of nanobiotechnology · 2026Review
- [Optogenetic reactivation of dormant cone photoreceptors].Die Ophthalmologie · 2026Article
- Rapid dynamics of dorsal raphe serotonin neurons regulate the strength of visual attention.Nature communications · 2026Article
- A large-scale optogenetic neurophysiology platform for improving accessibility in non-human primate behavioral experiments.Nature communications · 2026Article
- Prefrontal chandelier cells encode stimulus salience to influence learning in male mice.Nature communications · 2026Article
- A neural circuit basis for reward-induced suppression of fear generalization and enhancement of fear extinction.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Bridging Model and Experiment in Systems Neuroscience with Cleo: The Closed-Loop, Electrophysiology, and Optophysiology Simulation Testbed.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Sex-associated circadian signaling signatures in the lateral hypothalamus.Frontiers in sleep · 2026Article
- Optogenetic vision restoration in the face of secondary and tertiary remodeling in the rd1 mouse retina.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
246 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 2 countries.
Amy S Chuong1] Media Lab, Department of Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [3] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Mitra L Miri1] Department of Neurobiology, Yale School of Medicine, Yale University, New Haven, Connecticut, USA. [2].
Volker Busskamp1] Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. [2] Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [3].
Gillian A C Matthews1] Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2].
Leah C Acker1] Media Lab, Department of Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [3] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [4].
Andreas T SørensenMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Andrew YoungMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Nathan C Klapoetke1] Media Lab, Department of Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [3] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Mike A Henninger1] Media Lab, Department of Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [3] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Suhasa B Kodandaramaiah1] Media Lab, Department of Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [3] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [4] George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.
Masaaki Ogawa1] Media Lab, Department of Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [3] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Shreshtha B RamanlalDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts, USA.
Rachel C BandlerMedia Lab, Department of Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Brian D AllenMedia Lab, Department of Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Craig R ForestGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.
Brian Y ChowDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Xue HanDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts, USA.
Yingxi LinMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Kay M TyePicower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Botond RoskaNeural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Jessica A Cardin1] Department of Neurobiology, Yale School of Medicine, Yale University, New Haven, Connecticut, USA. [2] Kavli Institute for Neuroscience, Yale University, New Haven, Connecticut, USA.
Edward S Boyden1] Media Lab, Department of Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [3] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
McGovern Institute for Brain Research · USMassachusetts Institute of Technology · USBoston University · USGeorgia Institute of Technology · USFriedrich Miescher Institute · CHUniversity of Pennsylvania · US
Funding
TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1985 to 2020
$25.6MNovel Platforms for Systematic Optical Control of Complex Neural Circuits In VivoR01DA029639 · NIDA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2010 to 2023
$6.7MHigh-throughput robotic analysis of integrated neuronal phenotypesR01EY023173 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S., FOREST, CRAIG · 2012 to 2016
$4.3MInhibitory regulation of cortical visual processingR01EY022951 · NEI · YALE UNIVERSITY · PI CARDIN, JESSICA A · 2013 to 2025
$4.0MLight-Actuatable NanoRobots for Molecular UncagingDP2NS082126 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI HAN, XUE · 2012 to 2017
$2.9MA Novel Strategy for Combating Obesity: Reprogramming Neural CircuitsDP2DK102256 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI TYE, KAY MAXINE · 2013 to 2018
$2.7MNovel Tools and Principles for Precisely Controlling Brain ActivityDP2OD002002 · OD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2007 to 2007
$2.5MGABAergic contributions to neural circuit deficits in schizophreniaR01MH102365 · NIMH · YALE UNIVERSITY · PI CARDIN, JESSICA A · 2014 to 2018
$2.1MThe Role of GABAergic Synaptic Plasticity in Neural Circuit FunctionsR01MH091220 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LIN, YINGXI · 2010 to 2014
$2.1MDissecting the Neural Circuits Encoding Positive and Negative ValenceR01MH102441 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TYE, KAY MAXINE · 2014 to 2018
$2.0MCRCNS: Gamma Rhythms and Cell AssembliesR01NS067199 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI KOPELL, NANCY · 2009 to 2013
$1.7MGenetically-Encoded Tools for Manipulation of Ion Channel and Receptor FunctionsR01NS075421 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2011 to 2014
$1.3MNCCDPHP CDC HHS 1DP2NS082126NEI NIH HHS R00 EY018407NEI NIH HHS R01 EY022951NEI NIH HHS R01 EY023173NIDA NIH HHS 1R01DA029639NIDA NIH HHS R01 DA029639NIDDK NIH HHS DP2 DK102256NIEHS NIH HHS P30 ES002109NIH HHS 1DP2OD002002NIH HHS DP2 OD002002NIH HHS DP2-OD-017366-01NIMH NIH HHS 1RC1MH088182NIMH NIH HHS 5R00MH085944NIMH NIH HHS R00 MH085944NIMH NIH HHS R01 MH091220NIMH NIH HHS R01 MH091220-01NIMH NIH HHS R01 MH102365NIMH NIH HHS R01 MH102441NIMH NIH HHS R01-MH102441-01NIMH NIH HHS RC1 MH088182NINDS NIH HHS 1R01NS067199NINDS NIH HHS 1R01NS075421NINDS NIH HHS 1R01NS081716NINDS NIH HHS 1R01NS087950NINDS NIH HHS 1R21NS078660NINDS NIH HHS DP2 NS082126NINDS NIH HHS R01 NS067199NINDS NIH HHS R01 NS075421NINDS NIH HHS R01 NS081716NINDS NIH HHS R01 NS087950NINDS NIH HHS R21 NS078660
Abstract
Optogenetic inhibition of the electrical activity of neurons enables the causal assessment of their contributions to brain functions. Red light penetrates deeper into tissue than other visible wavelengths. We present a red-shifted cruxhalorhodopsin, Jaws, derived from Haloarcula (Halobacterium) salinarum (strain Shark) and engineered to result in red light-induced photocurrents three times those of earlier silencers. Jaws exhibits robust inhibition of sensory-evoked neural activity in the cortex and results in strong light responses when used in retinas of retinitis pigmentosa model mice. We also demonstrate that Jaws can noninvasively mediate transcranial optical inhibition of neurons deep in the brains of awake mice. The noninvasive optogenetic inhibition opened up by Jaws enables a variety of important neuroscience experiments and offers a powerful general-use chloride pump for basic and applied neuroscience.
Indexed as
AnimalsBrain ChemistryHalobacterium salinarumHalorhodopsinsMiceMolecular Sequence DataNeural InhibitionNeuronsOptogeneticsRetinaHalorhodopsins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.