Trial reportBMC pediatrics2014
Mediterranean-style diet reduces metabolic syndrome components in obese children and adolescents with obesity.
Trial report in BMC pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04719052 (Mediterranean Enriched Diet for Tackling Youth Obesity), which is not on this map. Cited by 93 papers, 14 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mediterranean Enriched Diet for Tackling Youth Obesity
Who cites it
93 citing papers in PubMed, 14 syntheses or guidelines pooled it, 171 citations in OpenAlex.
- The Relationship Between Children's Diet and Risk Factors for Cardiovascular Disease.Nutrients · 2026Pooled it
- Efficacy of Mediterranean diet interventions on children and adolescents affected by overweight or obesity: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Comparison of the Mediterranean Diet and Other Therapeutic Strategies in Metabolic Syndrome: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Managing pediatric metabolic syndrome: a systematic review of current approaches.BMC pediatrics · 2025Pooled it
- Effect of olive oil consumption on diabetes risk: a dose-response meta-analysis.Journal of health, population, and nutrition · 2025Pooled it
- Pooled it
- Mediterranean Diet and Cardiometabolic Biomarkers in Children and Adolescents: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Epidemiological Impact of Metabolic Syndrome in Overweight and Obese European Children and Adolescents: A Systematic Literature Review.Nutrients · 2023Pooled it
- Mediterranean Diet-Based Interventions to Improve Anthropometric and Obesity Indicators in Children and Adolescents: A Systematic Review with Meta-Analysis of Randomized Controlled Trials.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Interventions to Treat Obesity in Mexican Children and Adolescents: Systematic Review and Meta-Analysis.Nutrition reviews · 2022Pooled it
- Pooled it
- Effectiveness and process evaluation in obesity and type 2 diabetes prevention programs in children: a systematic review and meta-analysis.BMC public health · 2021Pooled it
- Associations between dietary factors and obesity-related biomarkers in healthy children and adolescents - a systematic review.Nutrition journal · 2017Pooled it
- Selenium Homeostasis and Clustering of Cardiovascular Risk Factors: A Systematic Review.Acta bio-medica : Atenei Parmensis · 2017Pooled it
- A Mediterranean lifestyle obesity prevention intervention in preschoolers at risk: MELI-POP Study-a randomized controlled trial.European journal of pediatrics · 2026Trial
- Trial
- Effect of Monacolin K and COQ10 supplementation in hypertensive and hypercholesterolemic subjects with metabolic syndrome.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2018Trial
- Personalized Cardio-Metabolic Responses to an Anti-Inflammatory Nutrition Intervention in Obese Adolescents: A Randomized Controlled Crossover Trial.Molecular nutrition & food research · 2018Trial
- Article
- Combined Effects of Mediterranean Diet Adherence and Physical Activity on Metabolic Homeostasis and Beta-Cell Function in Male Adolescents.Nutrients · 2026Observational
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe beneficial effects of the Mediterranean diet have been amply proven in adults with cardiovascular risk factors. The effects of this diet have not been extensively assessed in pediatric populations with obesity, insulin resistance (IR) and metabolic syndrome (MetS). The aim of this study was to assess the efficacy of the Mediterranean style diet (MSD) to decrease cardiovascular risk factors in children and adolescents with obesity.
methodsParticipants were randomly assigned to a MSD rich in polyunsaturated fatty acids, fiber, flavonoids and antioxidants (60% of energy from carbohydrate, 25% from fat, and 15% from protein, (n = 24); or a standard diet (55% of carbohydrate, 30% from fat and 15% from protein, (n = 25), the caloric ingest was individualized. At baseline and 16-week of intervention, the glucose, triglycerides (TG), total cholesterol (TC), HDL-C, LDL-C were measured as well as the body composition and anthropometric data. The diet compliance was determined by the 24-hour recalls.Paired Student's t and Macnemar's test were used to compare effects in biochemical, body composition, anthropometric, and dietary variables.
resultsThe MSD group had a significantly decrease in BMI, lean mass, fat mass, glucose, TC, TG, HDL-C and LDL-C. (p < 0.05); the diet compliance increased consumption of omega 9 fatty acids, zinc, vitamin E, selenium, and decreased consumption of saturated fatty acids (p < 0.05). The standard diet group decrease in glucose levels and frequency of glucose >100 mg/dL (p < 0.05).
conclusionThe MSD improves the BMI, glucose and lipid profile in children and adolescents with obesity and any MetS component.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.