Evidence map›Paper›PMID 24997309›Full record

ArticleBiostatistics (Oxford, England)2015

Doubly robust estimation and causal inference in longitudinal studies with dropout and truncation by death.

Michelle Shardell, Gregory E Hicks, Luigi Ferrucci

Abstract read
In one paragraph

Article in Biostatistics (Oxford, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Sex Differences in Recovery Across Multiple Domains Among Older Adults With Hip Fracture.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Article
  8. Article
  9. Bayesian semi-parametric G-computation for causal inference in a cohort study with MNAR dropout and death.Journal of the Royal Statistical Society. Series C, Applied statistics · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Plasma Klotho and Frailty in Older Adults: Findings From the InCHIANTI Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Article
  14. Observational
  15. Article
  16. Soluble Tumor Necrosis Factor Alpha Receptor 1, Bone Resorption, and Bone Mineral Density in the Year Following Hip Fractures: The Baltimore Hip Studies.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
    Article
  17. Article
  18. Article
  19. Older men who sustain a hip fracture experience greater declines in bone mineral density at the contralateral hip than non-fractured comparators.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michelle ShardellDepartment of Epidemiology and Public Health, University of Maryland 660 West Redwood Street, Baltimore, MD 21201, USA mshardel@epi.umaryland.edu.
Gregory E HicksDepartment of Physical Therapy, University of Delaware 303 McKinly Lab, Newark, DE 19716, USA.
Luigi FerrucciNational Institute on Aging, 3001 S Hanover Street, Baltimore, MD 21225, USA.

Funding

Chronic Low Back Pain in Older Adults: The Role of Co-Existing Hip ImpairmentsR01AG041202 · NIA · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2012 to 2026
$8.4M
Statistical methods for vitamin D targets for functional outcomes in older adultsR01AG048069 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2015 to 2025
$4.3M
Statistical Methods to Correct for Proxy Bias in Studies of Older AdultsK25AG034216 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2011 to 2013
$401k
NIA NIH HHS K25AG034216NIA NIH HHS R01AG041202NIA NIH HHS R01 AG048069
6 · The paper itself

Abstract

Motivated by aging research, we propose an estimator of the effect of a time-varying exposure on an outcome in longitudinal studies with dropout and truncation by death. We use an inverse-probability weighted (IPW) estimator to derive a doubly robust augmented inverse-probability weighted (AIPW) estimator. IPW estimation involves weights for the exposure mechanism, dropout, and mortality; AIPW estimation additionally involves estimating data-generating models via regression. We demonstrate that the estimators identify a causal contrast that is a function of principal strata effects under a set of assumptions. Simulations show that AIPW estimation is unbiased when weights or outcome regressions are correct, and that AIPW estimation is more efficient than IPW estimation when all models are correct. We apply the method to a study of vitamin D and gait speed among older adults.

Indexed as

Data Interpretation, StatisticalBiasHumansMortalityOutcome Assessment, Health CarePatient DropoutsCausal inferenceLongitudinal data analysisMissing dataObservational studies

Identifiers

PMID24997309
PMCPMC4263224

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.